心外膜脂肪细胞大小与体重指数无关。

Epicardial adipocyte size does not correlate with body mass index.

机构信息

Department of Physiology, HeartOtago, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand.

出版信息

Cardiovasc Pathol. 2019 Nov-Dec;43:107144. doi: 10.1016/j.carpath.2019.07.003. Epub 2019 Aug 1.

DOI:10.1016/j.carpath.2019.07.003

PMID:31491646

Abstract

BACKGROUND

Epicardial adipose tissue (EAT) deposition has a strong association with aspects of metabolic dysfunction, including obesity. The size of the EAT adipocytes in relation to obesity, however, has rarely been researched. Therefore, to contextualise EAT within the broader framework of pathophysiological adipocyte size changes in obesity, we aimed to determine whether EAT adipocyte size is associated with body mass index (BMI).

METHODS

During routine post-mortem examination, adipose tissue biopsies were obtained from four depots of 43 cases, including EAT, as well as pericardial (PAT), appendix mesenteric (AAT), and clavicular subcutaneous (SAT) adipose tissues. Tissues were fixed, sectioned, and stained using haematoxylin and eosin. The size (measured as area) of each adipocyte imaged from the depots was analysed in relation to BMI.

RESULTS

Mean size of EAT adipocytes was significantly smaller than that from SAT and AAT depots, while not differing from PAT adipocytes. BMI positively correlated with the size of adipocytes isolated from SAT (r=0.5893, P<.0001), PAT (r=0.5854, P<.0001), and AAT (r=0.5829, P<.0001) depots, but not from EAT (r=0.1242, P=.4274), even after multivariate adjustment for age and sex.

CONCLUSIONS

EAT adipocyte size is not associated with increased BMI despite significant associations within adipocytes from other adipose depots.

摘要

背景

心外膜脂肪组织（EAT）的沉积与代谢功能障碍的各个方面密切相关，包括肥胖。然而，EAT 脂肪细胞的大小与肥胖的关系很少被研究。因此，为了将 EAT 置于肥胖症中病理生理脂肪细胞大小变化的更广泛框架内，我们旨在确定 EAT 脂肪细胞大小是否与体重指数（BMI）相关。

方法

在常规尸检期间，从 43 例患者的四个脂肪组织中获取脂肪组织活检，包括 EAT，以及心包（PAT）、阑尾系膜（AAT）和锁骨皮下（SAT）脂肪组织。组织用苏木精和伊红固定、切片和染色。从各脂肪组织中成像的每个脂肪细胞的大小（以面积测量）与 BMI 相关进行分析。

结果

EAT 脂肪细胞的平均大小明显小于 SAT 和 AAT 脂肪细胞，但与 PAT 脂肪细胞没有差异。BMI 与 SAT（r=0.5893，P<.0001）、PAT（r=0.5854，P<.0001）和 AAT（r=0.5829，P<.0001）脂肪细胞中分离的脂肪细胞大小呈正相关，但与 EAT 脂肪细胞（r=0.1242，P=.4274）无关，即使在年龄和性别进行多变量调整后也是如此。