International Master/Ph.D. Program in Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan.
Department of Health Behavior, Environment, and Social Medicine, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Yogyakarta 55281, Indonesia.
Int J Environ Res Public Health. 2019 Sep 5;16(18):3258. doi: 10.3390/ijerph16183258.
Findings on risk detection for having metabolic syndrome (MetS) components, each of which may individually increase the risk of disease and mortality, are limited in young adults. In this study, we aimed to calculate the likelihood of having ≥1 MetS component in normoweight young adults using two different metabolic health criteria. We recruited 1182 normoweight young adults from the Taiwan Survey on the Prevalence of Hypertension, Hyperglycemia, and Hyperlipidemia and the National Health Interview Survey (aged 16-45 years, 39% male, body mass index = 18.5-22.99, all without MetS) and followed them for 5 years. Metabolic health criteria were derived from the Harmonized criteria (unhealthy if showing abnormality in one or two MetS components) and the triglyceride-glucose index (TyG-i; unhealthy if TyG-i was in the >75th percentile). Odds ratio (OR) and 95% confidence interval (CI) estimations for having ≥1 MetS component and for having each MetS component in 5 years were assessed using multivariable-adjusted logistic regression. We observed a significantly increased likelihood of the presence of ≥1 MetS component in the unhealthy group by using the Harmonized criteria and TyG-i (adjusted OR (aOR); 95%CI: 2.67; 2.04-3.49 and 2.1; 1.57-2.82, respectively). The areas under the receiver-operating characteristics curves were 0.679 and 0.652 for the final models using Harmonized and TyG-i criteria, respectively. These findings support the recommendation of treating any metabolic component abnormality, even in young adults without a MetS diagnosis.
在代谢综合征 (MetS) 成分的风险检测方面，每个成分都可能单独增加疾病和死亡率的风险，其研究结果在年轻人中是有限的。在这项研究中，我们旨在使用两种不同的代谢健康标准来计算体重正常的年轻成年人中存在≥1 个 MetS 成分的可能性。我们从台湾高血压、高血糖和高血脂流行调查和全国健康访谈调查中招募了 1182 名体重正常的年轻成年人（年龄在 16-45 岁之间，39%为男性，体重指数=18.5-22.99，均无 MetS），并对他们进行了 5 年的随访。代谢健康标准来自协调标准（如果一个或两个 MetS 成分异常，则不健康）和甘油三酯-葡萄糖指数（TyG-i；如果 TyG-i 处于>75 百分位，则不健康）。使用多变量调整后的逻辑回归评估了使用 Harmonized 标准和 TyG-i 标准≥1 个 MetS 成分和 5 年内每个 MetS 成分的存在的比值比 (OR) 和 95%置信区间 (CI)。我们观察到，使用 Harmonized 标准和 TyG-i 标准，不健康组中存在≥1 个 MetS 成分的可能性显著增加（调整后的 OR (aOR)；95%CI：2.67；2.04-3.49 和 2.1；1.57-2.82）。使用 Harmonized 和 TyG-i 标准的最终模型的受试者工作特征曲线下面积分别为 0.679 和 0.652。这些发现支持了治疗任何代谢成分异常的建议，即使在没有 MetS 诊断的年轻成年人中也是如此。
