Department of Rehabilitation Medicine, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, South Korea.
Department of Rehabilitation Medicine, Seoul National University College of Medicine, SMG-SNU Boramae Medical Center, Seoul, South Korea.
BMJ Open. 2019 Sep 5;9(9):e032443. doi: 10.1136/bmjopen-2019-032443.
Sarcopenia in the lumbar paraspinal muscles is receiving renewed attention as a cause of spinal degeneration. However, there are few studies on the precise concept and diagnostic criteria for spinal sarcopenia. Here, we develop the concept of spinal sarcopenia in community-dwelling older adults. In addition, we aim to observe the natural ageing process of paraspinal and back muscle strength and investigate the association between conventional sarcopenic indices and spinal sarcopenia.
This is a prospective observational cohort study with 120 healthy community-dwelling older adults over 4 years. All subjects will be recruited in no sarcopenia, possible sarcopenia or sarcopenia groups. The primary outcomes of this study are isokinetic back muscle strength and lumbar paraspinal muscle quantity and quality evaluated using lumbar spine MRI. Conventional sarcopenic indices and spine specific outcomes such as spinal sagittal balance, back performance scale and Sorenson test will also be assessed.
Before screening, all participants will be provided with oral and written information. Ethical approval has already been obtained from all participating hospitals. The study results will be disseminated in peer-reviewed publications and conference presentations.
NCT03962530.
腰椎旁脊柱肌的肌肉减少症作为脊柱退变的一个原因正重新受到关注。然而，关于脊柱肌肉减少症的确切概念和诊断标准的研究很少。在这里，我们提出了社区居住的老年人群中脊柱肌肉减少症的概念。此外，我们旨在观察脊柱旁和背部肌肉力量的自然老化过程，并研究常规肌肉减少症指标与脊柱肌肉减少症之间的关系。
这是一项前瞻性观察性队列研究，涉及 120 名 4 年以上无肌肉减少症、可能肌肉减少症或肌肉减少症的健康社区居住的老年人。所有受试者将被招募到无肌肉减少症、可能肌肉减少症或肌肉减少症组。本研究的主要结果是使用腰椎 MRI 评估等速背肌力量和腰椎旁脊柱肌肉数量和质量。还将评估常规肌肉减少症指标和脊柱特异性结果，如脊柱矢状平衡、背部表现量表和 Sorenson 测试。
在筛选之前，将向所有参与者提供口头和书面信息。所有参与医院均已获得伦理批准。研究结果将在同行评议的出版物和会议报告中公布。
NCT03962530。
