Singh Manish Pal, Gupta Avneet, Sisodia Siddhraj Singh
Bhupal Nobles University, Department of pharmacology, Bhupal Nobles College of Pharmacy, 313002 Udaipur, India.
SGT University, Department of pharmacology, SGT College of Pharmacy, 122505 Gurugram, India.
J Complement Integr Med. 2019 Sep 7;17(2):/j/jcim.2020.17.issue-2/jcim-2019-0133/jcim-2019-0133.xml. doi: 10.1515/jcim-2019-0133.
Background Diabetic wound are the major problem of society because of its delay healing of wound in hyperglycemia patient. The target of this study need to know the gallic acid compelling synergistically wound healing in diabetic animals as it is available in fruit extract or is more effective in given pure form in diabetic animals. Methods The wound healing effects of fruit extract Terminalia bellerica Roxb. and gallic acid were evaluated in experimentally induced hyperglycemic animals. In this investigation, excision and dead space wound models were used. The contraction wound %, re-epithelialization days, area of scar, histopathological examination of tissue, hydroxyproline level and weight of tissue granuloma were evaluated in this study. Results Terminalia bellerica fruit extract (400 mg/Kg) and gallic acid (200 mg/Kg) have been ingested by orally in streptozotocin induced diabetic rats. They were founded significantly (p<0.05) improved percentage wound contraction and decreased the size of scar area and days of re-epithelialization in excision wound model. Also, they were improved the level of hydroxyproline level in diabetic rats as compared to diabetic control group in dead space wound model. Standard drug vitamin C was also founded significantly improved wound healing activity in rats. These results suggested that treated groups accelerated wound healing activity in diabetic rat. Conclusions The observations and results obtained in the present study indicated the wound healing efficacy of fruit ethanolic extract and gallic acid in diabetic animals. Yet, the wound healing effect was increasingly reported with gallic acid.
背景 糖尿病伤口是一个主要的社会问题，因为高血糖患者的伤口愈合延迟。本研究的目的是了解没食子酸在糖尿病动物中协同促进伤口愈合的作用，因为它存在于水果提取物中，或者以纯形式给予糖尿病动物时更有效。方法 在实验性诱导的高血糖动物中评估诃子果实提取物和没食子酸的伤口愈合效果。在这项研究中，使用了切除和死腔伤口模型。本研究评估了伤口收缩百分比、再上皮化天数、瘢痕面积、组织病理检查、羟脯氨酸水平和组织肉芽肿重量。结果 诃子果实提取物（400mg/Kg）和没食子酸（200mg/Kg）经口服给予链脲佐菌素诱导的糖尿病大鼠。在切除伤口模型中，它们显著（p<0.05）提高了伤口收缩百分比，减小了瘢痕面积大小和再上皮化天数。此外，在死腔伤口模型中，与糖尿病对照组相比，它们提高了糖尿病大鼠的羟脯氨酸水平。标准药物维生素C也被发现能显著改善大鼠的伤口愈合活性。这些结果表明治疗组加速了糖尿病大鼠的伤口愈合活性。结论 本研究获得的观察结果和结果表明了水果乙醇提取物和没食子酸在糖尿病动物中的伤口愈合功效。然而，没食子酸的伤口愈合效果报道越来越多。
