Kaur Sarabjit, Jaggi R K
University Institute of Pharmaceutical Sciences, Punjab University, Chandigarh.
Indian J Exp Biol. 2010 Sep;48(9):925-30.
The petroleum ether (PE), chloroform (CH), ethanol (ETH) and water extracts of Terminalia bellerica and T. chebula fruits were evaluated for their analgesic activity using the tail immersion model in mice. The ethanolic extracts of both the plants exhibited analgesic response at 200,400 and 800mg/kg. The studies were further carried for 15 days to evaluate the effect of these extracts in chronic pain and maximum analgesic response was observed on 14th day in both the plants. Phytochemical investigation of ethanolic extract of the fruits of Terminalia bellerica and T. chebula revealed the presence of saponins, triterpenoids, carbohydrates, tannins and proteins. The results indicate that fruits of T. bellerica and T. chebula could be considered as potential candidate for bioactivity-guided isolation of natural analgesic agents used in the management of chronic pain.
采用小鼠尾部浸没法，对诃子和毛诃子果实的石油醚（PE）、氯仿（CH）、乙醇（ETH）及水提取物的镇痛活性进行了评估。两种植物的乙醇提取物在200、400和800mg/kg剂量时均表现出镇痛反应。研究进一步持续了15天，以评估这些提取物对慢性疼痛的影响，在第14天观察到两种植物均出现最大镇痛反应。对诃子和毛诃子果实乙醇提取物的植物化学研究表明，其中存在皂苷、三萜类化合物、碳水化合物、单宁和蛋白质。结果表明，诃子和毛诃子果实可被视为用于慢性疼痛管理的天然镇痛剂生物活性导向分离的潜在候选物。
