Section of Neurobiology, University of California, San Diego, CA, USA; Department of Physics, University of California, San Diego, CA, USA.
Department of Biomedical Engineering, University of Texas, Austin, TX, USA.
Neuron. 2019 Sep 25;103(6):1005-1015. doi: 10.1016/j.neuron.2019.08.011. Epub 2019 Sep 5.
The classic approach to measure the spiking response of neurons involves the use of metal electrodes to record extracellular potentials. Starting over 60 years ago with a single recording site, this technology now extends to ever larger numbers and densities of sites. We argue, based on the mechanical and electrical properties of existing materials, estimates of signal-to-noise ratios, assumptions regarding extracellular space in the brain, and estimates of heat generation by the electronic interface, that it should be possible to fabricate rigid electrodes to concurrently record from essentially every neuron in the cortical mantle. This will involve fabrication with existing yet nontraditional materials and procedures. We further emphasize the need to advance materials for improved flexible electrodes as an essential advance to record from neurons in brainstem and spinal cord in moving animals.
经典的测量神经元尖峰反应的方法涉及使用金属电极来记录细胞外电势。从 60 多年前的一个单一记录点开始，这项技术现在已经扩展到越来越多的记录点和更高的密度。我们基于现有材料的机械和电气特性、信号噪声比的估计、大脑细胞外空间的假设以及电子接口产生的热量的估计，认为制造刚性电极以同时记录皮质层中的基本每个神经元是可行的。这将涉及使用现有的但非传统的材料和工艺进行制造。我们进一步强调需要开发改进的柔性电极材料，这是在移动动物中记录脑干和脊髓神经元的重要进展。
