Department of Radiation Oncology Mersin-Turkey, School of Medicine, Mersin University , Mersin , Turkey.
Department of Perfusion Technology, Vocational School of Medical Services, Mersin University , Mersin , Turkey.
Cancer Invest. 2019;37(9):489-500. doi: 10.1080/07357907.2019.1662434. Epub 2019 Sep 9.
Prostate cancer is the most common cancer and leading cause of cancer death for males. Imipramine (IMI), which is a tricyclic antidepressant, has also been shown to has antineoplastic effect. This study was performed to investigate the radiosensitizing effect of IMI on DU145 prostate cancer cell. Cells were divided into 4 groups. Cell index, apoptotic activity, cell cycle arrest, oxidative stress and EAG1 channel currents were determined in all groups. Our findings showed that combined treatment with IMI and radiotherapy (RAD) did not enhance radiosensitivity of DU145 cells but as unexpected finding, treatment of IMI alone was more effective in DU145 cells.
前列腺癌是男性最常见的癌症和癌症死亡的主要原因。三环抗抑郁药丙咪嗪（IMI）也已被证明具有抗肿瘤作用。本研究旨在探讨 IMI 对 DU145 前列腺癌细胞的放射增敏作用。将细胞分为 4 组。所有组均测定细胞指数、细胞凋亡活性、细胞周期阻滞、氧化应激和 EAG1 通道电流。我们的研究结果表明，IMI 联合放疗（RAD）并没有增强 DU145 细胞的放射敏感性，但出乎意料的是，单独使用 IMI 治疗对 DU145 细胞更有效。
