Wong C S, Palmer G S, Cynamon M H
Department of Medicine, Veterans Administration Medical Center, Syracuse, New York 13210.
J Antimicrob Chemother. 1988 Dec;22(6):863-6. doi: 10.1093/jac/22.6.863.
The in-vitro susceptibility of Mycobacterium tuberculosis, M. bovis, and M. kansasii to amoxycillin alone and in combination with 2 mg/l of clavulanic acid was evaluated by broth dilution. The MIC90 of amoxycillin plus clavulanic acid was 4 mg/l compared with greater than 32 mg/l for amoxycillin alone when tested against M. tuberculosis (n = 27). M. bovis (n = 8) was the most susceptible species with an MIC90 of amoxycillin 8 mg/l, compared with 0.5 mg/l for the combination. M. kansasii (n = 6), with an MIC90 of 16 mg/l for amoxycillin plus clavulanic acid was more resistant than either M. tuberculosis or M. bovis. Ticarcillin plus clavulanic acid with an MIC90 of 32 mg/l was less active against M. tuberculosis (n = 28) than amoxycillin plus clavulanic acid. The addition of clavulanic acid to amoxycillin greatly improves its in-vitro activity against M. tuberculosis and M. bovis.
采用肉汤稀释法评估了结核分枝杆菌、牛分枝杆菌和堪萨斯分枝杆菌对单独使用阿莫西林以及与2mg/L克拉维酸联合使用时的体外敏感性。对结核分枝杆菌（n = 27）进行测试时，阿莫西林加克拉维酸的MIC90为4mg/L，而单独使用阿莫西林时大于32mg/L。牛分枝杆菌（n = 8）是最敏感的菌种，阿莫西林的MIC90为8mg/L，联合用药时为0.5mg/L。堪萨斯分枝杆菌（n = 6），阿莫西林加克拉维酸的MIC90为16mg/L，比结核分枝杆菌或牛分枝杆菌更具耐药性。替卡西林加克拉维酸的MIC90为32mg/L，对结核分枝杆菌（n = 28）的活性低于阿莫西林加克拉维酸。在阿莫西林中添加克拉维酸可大大提高其对结核分枝杆菌和牛分枝杆菌的体外活性。
