Qin Feng-Jun, Hu Xiao-Hua, Chen Zhong, Chen Xu, Shen Yu-Ming
Department of Burns, Beijing Jishuitan Hospital, Beijing, People's Republic of China.
Drug Des Devel Ther. 2019 Aug 13;13:2827-2832. doi: 10.2147/DDDT.S215927. eCollection 2019.
Tiopronin is an antioxidant. This study investigated the protective effect of tiopronin on oxidative stress in patients with severe burns.
Patients aged between 16 and 65 years old with >30% body surface area burns admitted to our burn unit from July 2011 to September 2016 were randomly divided into 3 groups: group A treated with tiopronin (15 mg/kg. 24 hrs), group B with vitamin C (792 mg/kg. 24 hrs), the other group with standard treatment (group C). All 3 groups also received standard treatment. Blood superoxide dismutase (SOD), malondialdehyde (MDA), and the biochemical indexes of liver, kidney, and heart were determined before treatment and 24 and 48 hrs after treatment. Samples from 8 normal healthy adult volunteers were also measured. The resuscitation fluid volume requirement for the first 24 hrs was calculated for 3 groups.
The serum levels of MDA and the biochemical indexes in severely burned patients were higher than those in healthy volunteers (<0.01). The serum SOD level of burn patients was lower (<0.01). After treatment, the levels of SOD increased, the levels of MDA decreased, and the biochemical indexes of heart, liver, and kidney improved; these changes were more obvious in group A and group B compared to group C (<0.05), and these changes were more obvious in group A compared to group B (<0.05) at 48 hrs after treatment. There is less resuscitation fluid volume requirement to maintain adequate stable hemodynamic and urine output in the first 24 hrs in group A and group B compared to group C (<0.05).
Treatment with tiopronin could exert protective effects against burn-induced oxidative tissue damage and multiple-organ dysfunction, and also could reduce the volume of required fluid resuscitation in severely burned patients.
硫普罗宁是一种抗氧化剂。本研究探讨硫普罗宁对严重烧伤患者氧化应激的保护作用。
选取2011年7月至2016年9月入住我院烧伤科、年龄在16至65岁、烧伤面积>30%体表面积的患者，随机分为3组：A组接受硫普罗宁治疗（15mg/kg，24小时），B组接受维生素C治疗（792mg/kg，24小时），另一组接受标准治疗（C组）。所有3组均接受标准治疗。在治疗前、治疗后24小时和48小时测定血液中超氧化物歧化酶（SOD）、丙二醛（MDA）以及肝、肾、心的生化指标。还对8名正常健康成年志愿者的样本进行了检测。计算3组患者前24小时的复苏液需求量。
严重烧伤患者的血清MDA水平和生化指标高于健康志愿者（<0.01）。烧伤患者的血清SOD水平较低（<0.01）。治疗后，SOD水平升高，MDA水平降低，心、肝、肾的生化指标改善；与C组相比，A组和B组的这些变化更明显（<0.05），且在治疗后48小时，A组与B组相比这些变化更明显（<0.05）。与C组相比，A组和B组在最初24小时维持足够稳定的血流动力学和尿量所需的复苏液量更少（<0.05）。
硫普罗宁治疗可对烧伤引起的组织氧化损伤和多器官功能障碍发挥保护作用，还可减少严重烧伤患者所需的液体复苏量。
