Moukayed Meis, Grant William B
School of Arts and Sciences, American University in Dubai, Dubai, UAE.
Sunlight, Nutrition, and Health Research Center, San Francisco, CA 94164-1603, USA.
Diabetes Metab Syndr Obes. 2019 Aug 16;12:1437-1447. doi: 10.2147/DMSO.S176933. eCollection 2019.
The global death toll from noncommunicable diseases is exceptionally high, reported to cause 71% of global deaths worldwide. Metabolic syndrome risk factors, especially excessive adiposity and obesity, are at the heart of the problem resulting in increased co-morbidities such as cardiometabolic diseases and cancer, increased health costs, poorer quality of life, and shortened survival. Vitamin D can positively reverse many of these adverse effects and outcomes through blocking signaling mechanisms that predispose to cardiometabolic and metastatic disease. As an affordable natural agent, vitamin D can be used to counteract obesity-induced inflammation, block early adipogenesis, enhance glucose uptake, counteract hyperleptinemia, ameliorate insulin resistance, and reduce hypertension. This is supported by data from in vitro, in vivo and epidemiological studies and clinical trials. We propose that everyone in general and obese patients in particular consider raising 25-hydroxyvitamin D levels through UVB exposure and/or supplemental vitamin D intake to reduce cardiometabolic and metastatic disease and increase longevity.
据报道，全球非传染性疾病的死亡人数极高，占全球总死亡人数的71%。代谢综合征的危险因素，尤其是过度肥胖，是导致问题的核心，会增加诸如心脏代谢疾病和癌症等合并症，增加医疗成本，降低生活质量，并缩短生存期。维生素D可以通过阻断易引发心脏代谢和转移性疾病的信号传导机制，积极扭转许多这些不良影响和后果。作为一种价格亲民的天然物质，维生素D可用于对抗肥胖引起的炎症，阻断早期脂肪生成，增强葡萄糖摄取，对抗高瘦素血症，改善胰岛素抵抗，并降低高血压。体外、体内、流行病学研究及临床试验的数据均支持这一点。我们建议，一般人群尤其是肥胖患者应考虑通过紫外线B照射和/或补充维生素D摄入来提高25-羟基维生素D水平，以减少心脏代谢和转移性疾病并延长寿命。
