Barikani Ameneh, Javadi Maryam, Rafiei Sima
School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran.
Children Growth Research Center, Qazvin University of Medical Sciences, Qazvin, Iran.
Int J Endocrinol Metab. 2019 Jun 2;17(3):e81062. doi: 10.5812/ijem.81062. eCollection 2019 Jul.
Recent literature has mentioned that people with sleep disorder, experience insulin sensitivity reduction and accordingly higher levels of blood glucose.
This study aimed to investigate the relationship between sleep quality and blood lipid composition in patients with diabetes referring to Minoodar health center in Qazvin, Iran in 2017.
Sleep duration and quality were assessed in 347 patients with diabetes using the Pittsburgh sleep quality index (PSQI). The glycosylated hemoglobin A1c (HbA1c) test was used to measure the glycemic control and total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), and high-density lipoprotein cholesterol (HDL-C) were used to determine blood lipid composition of the patients. Multiple regression analyses were applied to examine the associations between sleep measures and HbA1c and lipid parameters using SPSS version 20.
The patients in the poor sleep quality group had higher levels of fasting blood sugar (FBS) (146.07 ± 57.06 versus 132.8 ± 53.3 mg/dL, P = 0.02), body mass index (BMI) (29.1 ± 3.9 versus 27.6 ± 4.2 kg/m, P = 0.005) and total cholesterol (209.9 ± 53.4 versus 193.4 ± 45.8, P = 0.02). Furthermore, the patients with short sleep duration had higher total cholesterol level compared with long sleep and medium sleep duration group (202.3 ± 50.2 versus 196.6 ± 47.7 and 195.7 ± 47.4, respectively, P = 0.05). Among different PSQI measures, subjective sleep quality was associated with lower TC and TG in unadjusted models (β = -0.0.1, P = 0.05). Furthermore, greater sleep disturbance was positively linked with higher levels of TC and TG (β = 0.1, P = 0.01 and β = 0.02, P = 0.05).
In an Iranian population with diabetes living in Qazvin city, sleep disorder is common and as study findings revealed sleep quality was recognized as an influencing factor on some of the lipid profiles, including TC and TG. Thus sleep assessment of patients with type 2 diabetes to find the early recognition of their sleep disorder should be considered an important part of the patients' treatment.
近期文献提到，睡眠障碍患者存在胰岛素敏感性降低，进而血糖水平升高。
本研究旨在调查2017年伊朗加兹温市米努达尔健康中心糖尿病患者的睡眠质量与血脂成分之间的关系。
使用匹兹堡睡眠质量指数（PSQI）对347例糖尿病患者的睡眠时间和质量进行评估。采用糖化血红蛋白A1c（HbA1c）检测来衡量血糖控制情况，使用总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）、甘油三酯（TG）和高密度脂蛋白胆固醇（HDL-C）来确定患者的血脂成分。使用SPSS 20版进行多元回归分析，以检验睡眠指标与HbA1c及血脂参数之间的关联。
睡眠质量差的患者空腹血糖（FBS）水平更高（146.07±57.06对132.8±53.3mg/dL，P = 0.02）、体重指数（BMI）更高（29.1±3.9对27.6±4.2kg/m，P = 0.005）以及总胆固醇更高（209.9±53.4对193.4±45.8，P = 0.02）。此外，与长睡眠时间和中等睡眠时间组相比，睡眠时间短的患者总胆固醇水平更高（分别为202.3±50.2对196.6±47.7和195.7±47.4，P = 0.05）。在不同的PSQI指标中，在未调整模型中，主观睡眠质量与较低的TC和TG相关（β = -0.1，P = 0.05）。此外，更大的睡眠干扰与更高的TC和TG水平呈正相关（β = 0.1，P = 0.01；β = 0.02，P = 0.05）。
在加兹温市的伊朗糖尿病患者群体中，睡眠障碍很常见，且研究结果显示睡眠质量被认为是包括TC和TG在内的一些血脂指标的影响因素。因此，对2型糖尿病患者进行睡眠评估以早期识别其睡眠障碍应被视为患者治疗的重要组成部分。
