Zhang Di, Zhou Juan, Gao Jie, Wu Ri-Ying, Huang Ying-Long, Jin Qin-Wen, Chen Jian-Si, Tang Wei-Zhong, Yan Lin-Hai
Department of Gastrointestinal Surgery, Affiliated Tumor Hospital of Guangxi Medical University Nanning 530021, Guangxi Zhuang Autonomous Region, China.
Guangxi Clinical Research Center for Colorectal Cancer Nanning 530021, Guangxi Zhuang Autonomous Region, China.
Am J Cancer Res. 2019 Aug 1;9(8):1504-1516. eCollection 2019.
The relevance of the dysregulation of snoRNAs in human cancer has been widely investigated and has challenged the view that snoRNAs merely function as house-keeping genes for the posttranscriptional modification of rRNAs. Accumulating evidence has shown the intimate connection between snoRNAs and proliferation, apoptosis, invasion and migration of tumor cells via manual intervention patterns of snoRNA expression. In this review, we focused on how snoRNAs are dysregulated and its regulation of the formation and development of cancer. We summarized the non-classical functions of snoRNAs in the context of their regulations of the signaling pathways involving PI3K-AKT and K-Ras and p53-dependant manner. Under these novel functions and characteristics, snoRNAs can act as potential and feasible biomarkers for diagnosis. Simultaneously, these promising therapeutic strategies should be considered to counteract the perturbations of snoRNAs.
小核仁RNA（snoRNAs）失调在人类癌症中的相关性已得到广泛研究，并且挑战了snoRNAs仅仅作为rRNA转录后修饰管家基因的观点。越来越多的证据表明，通过snoRNA表达的人工干预模式，snoRNAs与肿瘤细胞的增殖、凋亡、侵袭和迁移之间存在密切联系。在本综述中，我们重点关注snoRNAs如何失调及其对癌症形成和发展的调控。我们总结了snoRNAs在其对涉及PI3K-AKT和K-Ras以及p53依赖性方式的信号通路调控背景下的非经典功能。基于这些新功能和特性，snoRNAs可作为潜在且可行的诊断生物标志物。同时，应考虑这些有前景的治疗策略来对抗snoRNAs的扰动。
