Chen Haijun, Ding Ke, Zhao Jingjing, Chao Herta H, Li Chiang-Shan R, Cheng Huaidong
Department of Oncology, The Second Affiliated Hospital of Anhui Medical University Hefei 230601, Anhui, China.
Cancer Center, VA Connecticut Healthcare System West Haven, CT 06516, USA.
Am J Cancer Res. 2019 Aug 1;9(8):1776-1785. eCollection 2019.
To investigate chemotherapy-related cognitive impairment (CRCI) in breast cancer patients with different hormone receptor (HR) expression and its neural mechanisms, forty BC patient were enrolled in this study and were divided into two groups. HR+ group was composed of twenty-one patients with Estrogen Receptor (ER)+/Progesterone Receptor (PR) +, HR- group included nineteen patients with ER-/PR-. A battery of neuropsychological tests and resting-state functional magnetic resonance imaging (rs-fMRI) examinations were administered to all subjects. The functional connectivity of the dorsolateral prefrontal cortex (DLPFC) of the patients was calculated from the resting-state fMRI data, and the correlation between the DLPFC's connectivity and the neuropsychological test was analyzed. The functional connectivity (FC) of the left dorsolateral prefrontal cortex (DLPFC) with the left precuneus (PCU), the right DLPFC with the right precuneus and the right superior frontal gyrus (SFG) of the HR- group were significantly increased compared to the HR+ group. Meanwhile, a significant positive correlation was found between the post-chemotherapy prospective memory (PM) score and the functional connectivity of the left DLPFC with the left precuneus in the HR- group. These findings suggest that different hormone receptor expression in patients with breast cancer may be associated with CRCI and provide evidence that the DLPFC functional connectivity (FC) strength may be selectively involved in CRCI in HR- group breast cancer patients, especially in regard to the subjective prospective memory.
为研究不同激素受体（HR）表达的乳腺癌患者化疗相关认知障碍（CRCI）及其神经机制，本研究纳入了40例乳腺癌患者并将其分为两组。HR+组由21例雌激素受体（ER）+/孕激素受体（PR）+的患者组成，HR-组包括19例ER-/PR-的患者。对所有受试者进行了一系列神经心理学测试和静息态功能磁共振成像（rs-fMRI）检查。根据静息态fMRI数据计算患者背外侧前额叶皮质（DLPFC）的功能连接性，并分析DLPFC连接性与神经心理学测试之间的相关性。与HR+组相比，HR-组左侧背外侧前额叶皮质（DLPFC）与左侧楔前叶（PCU）、右侧DLPFC与右侧楔前叶以及右侧额上回（SFG）之间的功能连接性（FC）显著增加。同时，在HR-组中，化疗后前瞻性记忆（PM）评分与左侧DLPFC与左侧楔前叶的功能连接性之间存在显著正相关。这些发现表明，乳腺癌患者不同的激素受体表达可能与CRCI有关，并提供了证据表明DLPFC功能连接性（FC）强度可能选择性地参与HR-组乳腺癌患者的CRCI，特别是在主观前瞻性记忆方面。
