Maliehe Afiat, Ghahremani Sara, Kharghani Sara, Ghazanfarpour Masumeh, Shariati Khatereh, Kazemi Maryam, Khadivzadeh Talat
Women's Health Research Center, Department of Obstetrics and Gynecology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Pediatrics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
J Menopausal Med. 2019 Aug;25(2):69-73. doi: 10.6118/jmm.18143. Epub 2019 Jun 5.
The purpose of the present overview of meta-analysis is to summarize and critically assess the effect of isoflavones and genistein on glucose metabolism among the peri- and post-menopausal women. Two independent authors searched the databases of MEDLINE, Scopus and Cochrane Library for meta-analysis. Three databases were searched from inception to January 2018. Methodological quality of each meta-analysis of randomized controlled trials was evaluated using the AMSTAR (a measurement tool used to assess systematic reviews). Four meta-analyses were included to the current overview. Fasting insulin levels and homeostatic model assessment of insulin resistance (HOMA-IR) values were significantly lower in peri-menopausal and postmenopausal. Two meta-analyses showed that treatment with isoflavones could not alter fasting blood glucose. However, one meta-analysis depicted that isoflavones significantly improved blood glucose levels in non-Asian postmenopausal women. Treatment with genistein could have significant beneficial effects on fasting insulin, blood glucose and HOMA-IR in comparison to the control group. Regardless of the population, the treatment with genistein is effective in improving fasting insulin, HOMA-IR and glucose levels. Nevertheless, the high heterogeneity among studies and poor methodology of reviews made it difficult to draw a definite conclusion on the positive impacts of soy on glucose metabolism.
本荟萃分析综述的目的是总结并批判性地评估异黄酮和染料木黄酮对围绝经期和绝经后女性葡萄糖代谢的影响。两位独立作者检索了MEDLINE、Scopus和Cochrane图书馆数据库中的荟萃分析。检索了这三个数据库从创建到2018年1月的内容。使用AMSTAR（一种用于评估系统评价的测量工具）评估每项随机对照试验荟萃分析的方法学质量。本综述纳入了四项荟萃分析。围绝经期和绝经后女性的空腹胰岛素水平和胰岛素抵抗稳态模型评估（HOMA-IR）值显著较低。两项荟萃分析表明，异黄酮治疗不能改变空腹血糖。然而，一项荟萃分析表明，异黄酮可显著改善非亚洲绝经后女性的血糖水平。与对照组相比，染料木黄酮治疗对空腹胰岛素、血糖和HOMA-IR可能有显著的有益影响。无论人群如何，染料木黄酮治疗在改善空腹胰岛素、HOMA-IR和血糖水平方面都是有效的。然而，研究之间的高度异质性和综述方法的不完善使得难以就大豆对葡萄糖代谢的积极影响得出明确结论。
