Department of Neurology, Amsterdam UMC, University of Amsterdam, Amsterdam Neuroscience, Meibergdreef, AZ Amsterdam, The Netherlands.
Department of Neurology, Radboud University Medical Center, Donders Institute for Brain, Cognition and Behavior, Nijmegen, The Netherlands.
J Parkinsons Dis. 2019;9(4):767-774. doi: 10.3233/JPD-191652.
Earlier research showed that Parkinson's disease is related to increased overall mortality, but it remains unclear which patient level factors are predictive of increased mortality in Parkinson's disease.
To jointly evaluate potential risk factors for overall and Parkinson's disease (PD) related mortality, we collected detailed information from a cohort of newly diagnosed PD patients which was consequently followed for over a decade.
A total of 133 consecutive patients with newly diagnosed PD were followed for at least 13 years. Survival analysis of observed mortality was used to evaluate risk factors for overall mortality, whereas survival analysis of mortality as corrected for the general population was used to evaluate risk factors for PD-related mortality.
Overall mortality increased with age, male sex, higher levodopa equivalent dose, and presence of mild cognitive impairment. PD-related mortality increased with earlier onset of Parkinson's disease, higher levodopa equivalent dose, and mild cognitive impairment.
Our findings provide confirmation and extension of risk factors for overall mortality and generate new insights into PD-related mortality.
早期研究表明，帕金森病与总死亡率增加有关，但目前尚不清楚哪些患者层面的因素可预测帕金森病患者的死亡率增加。
为了共同评估整体和帕金森病（PD）相关死亡率的潜在危险因素，我们从一组新诊断的 PD 患者中收集了详细信息，随后对其进行了长达十余年的随访。
共对 133 例新诊断的 PD 患者进行了随访，随访时间至少 13 年。采用观察性死亡率生存分析评估整体死亡率的危险因素，而采用校正一般人群死亡率的生存分析评估 PD 相关死亡率的危险因素。
总体死亡率随年龄、男性、左旋多巴等效剂量增加以及轻度认知障碍而增加。PD 相关死亡率随帕金森病发病年龄较早、左旋多巴等效剂量增加以及轻度认知障碍而增加。
我们的研究结果为整体死亡率的危险因素提供了证实和扩展，并为 PD 相关死亡率提供了新的见解。
