Gezon H M, Bither H D, Gibbs H C, Acker E J, Hanson L A, Thompson J K, Jorgenson R D
Atlantic Antibodies Inc., Windham, ME 04062.
Am J Vet Res. 1988 Nov;49(11):1817-23.
Mycobacterium paratuberculosis infection was detected in 2 goats in 1974 and in 5 goats in 1975; 5 of which were from a single herd. The magnitude of the subsequent epizootic in the goat herd was not recognized until 1977, when results of bacteriologic culture of fecal and tissue specimens, antibody determinations (agar-gel immuno-diffusion test), and histopathologic studies became available. By 1984, paratuberculosis had been diagnosed in 124 goats. Nearly all the goats were being used in antiserum production and had been given Freund complete adjuvant and human antigens. From 1974 to 1986, herd size varied from 100 to 300. The yearly incidence of paratuberculosis decreased from 13.2% (27 of 204 goats) in 1977 to 0% in 108 goats in 1985. The prevalence was higher in does. In goats that arrived on the farm in 1975 and before, 49 of 121 (40.5%) does developed paratuberculosis vs 41 of 120 (34.2%) wethers. In goats arriving on the farm in 1976 and after, 25 of 274 (8.5%) does and 9 of 216 (4.1%) wethers developed paratuberculosis. The average incubation period was approximately 4 years from arrival on the farm in every year except 1978, regardless of whether the goat was born on the farm or was purchased elsewhere.(ABSTRACT TRUNCATED AT 250 WORDS)
1974年在2只山羊中检测到副结核分枝杆菌感染，1975年在5只山羊中检测到；其中5只来自同一个畜群。直到1977年，当粪便和组织标本的细菌培养结果、抗体测定（琼脂凝胶免疫扩散试验）以及组织病理学研究结果可得时，才认识到随后山羊群中 epizootic 的规模。到1984年，已在124只山羊中诊断出副结核病。几乎所有山羊都用于抗血清生产，并已接种弗氏完全佐剂和人抗原。1974年至1986年，畜群规模从100只到300只不等。副结核病的年发病率从1977年的13.2%（204只山羊中的27只）降至1985年的0%（108只山羊中）。母羊中的患病率更高。在1975年及以前到达农场的山羊中，121只母羊中有49只（40.5%）患副结核病，而120只阉羊中有41只（34.2%）患病。在1976年及以后到达农场的山羊中，274只母羊中有25只（8.5%）和216只阉羊中有9只（4.1%）患副结核病。除1978年外，每年山羊到达农场后，平均潜伏期约为4年，无论山羊是在农场出生还是在其他地方购买。（摘要截断于250字）
