College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, Fujian, China.
Engineering Innovation Center of Marine Biological Resource Development and Utilization, Third Institute of Oceanography, Ministry of Natural Resources, Xiamen 361005, China.
Molecules. 2019 Sep 9;24(18):3274. doi: 10.3390/molecules24183274.
Pien-Tze-Huang (PTH) is a famous and commonly used traditional Chinese medicine formula in China. It was first formulated by a royal physician of the Ming Dynasty (around 1555 AD). Recently, PTH has attracted attention worldwide due to its beneficial effects against various diseases, especially cancer. This paper systematically reviewed the up-to-date information on its chemical composition, pharmacology, and clinical application. A range of chemical compounds, mainly ginsenosides and bile acids, have been identified and quantified from PTH. Pharmacological studies indicated that PTH has beneficial effects against various cancers, hepatopathy, and ischemic stroke. Furthermore, PTH has been used clinically to treat various diseases in China, such as colorectal cancer, liver cancer, and hepatitis. In summary, PTH is a potential agent with extensive therapeutic effects for the treatment of various diseases. However, the lack of information on the side effects and toxicity of PTH is a non-negligible issue, which needs to be seriously studied in the future.
黄精（PTH）是中国著名的常用中药方剂，最早由明朝（约公元 1555 年）的皇家医生创制。最近，由于其对各种疾病，特别是癌症的有益作用，PTH 引起了全球关注。本文系统地综述了其化学成分、药理学和临床应用的最新信息。从 PTH 中已经鉴定和定量了一系列化学化合物，主要是人参皂苷和胆汁酸。药理学研究表明，PTH 对各种癌症、肝病和缺血性中风有有益作用。此外，PTH 已在中国临床上用于治疗各种疾病，如结直肠癌、肝癌和肝炎。总之，PTH 是一种具有广泛治疗效果的潜在药物，可用于治疗各种疾病。然而，缺乏关于 PTH 的副作用和毒性的信息是一个不可忽视的问题，需要在未来认真研究。
