A review of environmental and occupational toxins in relation to sex ratio at birth.

A biased sex ratio at birth in human populations has been associated with numerous economic, psychosocial, environmental and demographic factors, and has been declining in most developed countries. One of the most often invoked explanation for this decline has been the growing environmental and occupational exposure to man-made chemicals that affect the reproductive physiology, putatively leading to altered sex ratios at birth. In this paper the current state of knowledge on the association between toxins and sex ratio at birth is presented and critically assessed. The evidence for the effect of toxins on sex ratio at birth is conflicting, with paternal exposure showing more promising results than maternal exposure. The obstacles in establishing more direct relation between toxins and sex ratio at birth involve different hormonal responses of mothers and fathers under the influence of toxins, the specific metabolic action of toxins, and the constraints of observational studies.