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[人类细胞中DNA修复障碍的机制。与DNA修复障碍相关的肌病患者淋巴细胞中的基因组不稳定性]

[Mechanisms of DNA repair disorders in human cells. Genome instability in lymphocytes of patients with myopathy related to DNA repair disorders].

作者信息

Chekova V V, Plotnikova N N, L'vova G N, Valikova T A, Il'inskikh N N

出版信息

Genetika. 1988 Dec;24(12):2202-7.

PMID:3150757
Abstract

Increased level of cytogenetic damages was observed in lymphocytes of 10 patients with muscular dystrophy (Duchenne, Erba, Landuzi--Degerin). Analysis of DNA repair synthesis revealed inhibition of this process in lymphocytes of 10 patients observed. On the other hand, decreased reactivation of vaccinia virus and increased level of virus mutagenesis induced by 4-nitroquinoline-1-oxide and bleomycin was noted in the experiments with lymphocytes of 3 patients observed.

摘要

在10例肌肉营养不良患者(杜氏、埃尔巴、兰杜齐 - 德热林型)的淋巴细胞中观察到细胞遗传学损伤水平升高。对DNA修复合成的分析显示,在所观察的10例患者的淋巴细胞中,这一过程受到抑制。另一方面,在对3例所观察患者的淋巴细胞进行的实验中,发现牛痘病毒的再激活降低,以及由4-硝基喹啉-1-氧化物和博来霉素诱导的病毒诱变水平增加。

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