Ogunwobi Olorunseun O, Kumar Adithya
Department of Biological Sciences, Hunter College of the City University of New York, New York, NY, United States.
Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, Cornell University, New York, NY, United States.
Front Oncol. 2019 Aug 27;9:834. doi: 10.3389/fonc.2019.00834. eCollection 2019.
Competitive endogenous RNA (ceRNA) networks have emerged as critical regulators of carcinogenesis. Their activity is mediated by various non-coding RNAs (ncRNAs), including long non-coding RNAs and microRNAs, which competitively bind to targets, thereby modulating gene expression and activity of proteins. Of particular interest, ncRNAs encoded by the 8q24 chromosomal region are associated with the development and progression of several human cancers, most prominently lncPVT1. Chemoresistance presents a significant obstacle in the treatment of cancer and is associated with dysregulation of normal cell processes, including abnormal proliferation, differentiation, and epithelial-mesenchymal transition. CeRNA networks have been shown to regulate these processes via both direct sponging/repression and epigenetic mechanisms. Here we present a review of recent literature examining the contribution of ncRNAs encoded by the locus and their associated ceRNA networks to the development of resistance to common chemotherapeutic agents used to treat human cancers.
竞争性内源RNA（ceRNA）网络已成为癌症发生的关键调节因子。它们的活性由各种非编码RNA（ncRNA）介导，包括长链非编码RNA和微小RNA，这些RNA竞争性地与靶标结合，从而调节基因表达和蛋白质活性。特别值得关注的是，8q24染色体区域编码的ncRNA与几种人类癌症的发生和发展相关，最显著的是lncPVT1。化疗耐药性是癌症治疗中的一个重大障碍，并且与正常细胞过程的失调有关，包括异常增殖、分化和上皮-间质转化。已证明ceRNA网络通过直接的海绵吸附/抑制和表观遗传机制来调节这些过程。在此，我们对最近的文献进行综述，探讨该位点编码的ncRNA及其相关ceRNA网络对用于治疗人类癌症的常见化疗药物耐药性发展的作用。
