Department of Life and Environmental Sciences, Polytechnic University of the Marche, Ancona, Italy.
Department of Drug Sciences, University of Catania, Catania, Italy.
J Pharm Sci. 2019 Dec;108(12):3769-3780. doi: 10.1016/j.xphs.2019.09.009. Epub 2019 Sep 12.
This review addresses a major question of importance to pharmaceutical scientists: how can novel drug delivery systems play a role in maximizing the UV protection of sunscreens? Because more and more people are being diagnosed with skin cancer each year than all other cancers combined, adequate sun protective measures are pivotal. In this context, the present review is to give an up-to-date overview on the different nanocarrier systems that have been explored so far for encapsulating different types of UV filters present on the market. The aim of these carrier systems is to prevent skin penetration and to enhance the photoprotective potential of sunscreen actives. For each supramolecular system, a brief description along with the studies, achievements, and pitfalls, on the type of UV actives inside them, ranging from classical UV filters to new generation of UV actives is given. A brief overview of UV filters encapsulated in microcarriers is also discussed.
新型药物输送系统如何在最大限度地提高防晒霜的紫外线防护方面发挥作用？由于每年被诊断出患有皮肤癌的人数超过所有其他癌症的总和，因此采取足够的防晒措施至关重要。在这种情况下，本综述旨在提供迄今为止已探索出的用于封装市场上存在的不同类型紫外线滤光剂的不同纳米载体系统的最新概述。这些载体系统的目的是防止皮肤渗透并增强防晒霜活性的光保护潜力。对于每种超分子系统，简要介绍了其中包含的紫外线活性物质的研究、成果和缺陷，范围从经典紫外线滤光剂到新一代紫外线活性物质。还讨论了封装在微载体中的紫外线滤光剂的简要概述。
