Postgraduate Program in Pharmaceutical Sciences, Federal University of Sergipe, São Cristóvão, Brazil.
Postgraduate Program in Health Sciences, Federal University of Sergipe, Aracaju, Brazil.
AAPS PharmSciTech. 2024 Sep 7;25(7):212. doi: 10.1208/s12249-024-02925-4.
UV radiation causes long- and short-term skin damage, such as erythema and skin cancer. Therefore, the use of sunscreens is extremely important. However, concerns about UV filter safety have prompted exploration into alternative solutions, with nanotechnology emerging as a promising avenue. This systematic review identified 23 experimental studies utilizing nanocarriers to encapsulate sunscreens with the aim of enhancing their efficacy and safety. Polymeric and lipid nanoparticles are frequently employed to encapsulate both organic and inorganic UV filters along with natural antioxidants. Nanocarriers have demonstrated benefits including reduced active ingredient usage, increased sun protection factor, and mitigated photoinstability. Notably, they also decreased the skin absorption of UV filters. In summary, nanocarriers represent a viable strategy for improving sunscreen formulations, offering enhanced physicochemical properties and bolstered photoprotective effects, thereby addressing concerns regarding UV filter safety and efficacy in cosmetic applications.
紫外线辐射会导致皮肤出现长期和短期的损伤，如红斑和皮肤癌。因此，防晒霜的使用极其重要。然而，人们对紫外线滤光剂安全性的担忧促使人们探索替代解决方案，纳米技术应运而生。本系统评价确定了 23 项利用纳米载体来封装防晒霜的实验研究，旨在提高其功效和安全性。聚合物和脂质纳米粒常用于封装有机和无机紫外线滤光剂以及天然抗氧化剂。纳米载体具有减少活性成分使用量、增加防晒因子和减轻光不稳定性等优点。值得注意的是，它们还减少了皮肤对紫外线滤光剂的吸收。总之，纳米载体是改善防晒霜配方的一种可行策略，提供了增强的物理化学性质和更强大的光保护效果，从而解决了化妆品应用中紫外线滤光剂安全性和功效方面的问题。
