Pereira L H, Melo A L, Mayrink W, De Resende D M
Departamento de Parasitologia, Universidade Federal de Minas Gerais, Brasil.
Parassitologia. 1988 May-Dec;30(2-3):187-96.
Callithrix penicillata is a good model for dermatotropic strains of some New World Leishmania species (L. mexicana mexicana, L. m. amazonensis, and L. braziliensis guyanensis). Both amastigotes and promastigotes readily infect these primates, with a relative short period of incubation. The developed lesions parallel those found in man, and despite the self healing presented by some marmosets, cell and serum immunological responses are presented. Skin alterations are confined to the site of inoculum, and visceralization is very rarely found. A good response to standard antimonial treatment makes the model useful for preclinical experiments with promising compounds.
帚尾狨是一些新大陆利什曼原虫物种（墨西哥利什曼原虫墨西哥亚种、亚马逊利什曼原虫和圭亚那利什曼原虫）亲皮性菌株的良好模型。无鞭毛体和前鞭毛体都很容易感染这些灵长类动物，潜伏期相对较短。所形成的病变与人类的病变相似，尽管一些狨猴会出现自愈情况，但仍会出现细胞和血清免疫反应。皮肤改变局限于接种部位，很少出现内脏化。对标准锑剂治疗反应良好，使得该模型可用于对有前景的化合物进行临床前实验。
