HectH9 劫持葡萄糖代谢以促进肿瘤生长。
HectH9 hijacks glucose metabolism to fuel tumor growth.
作者信息
Lee Hong-Jen, He Jiabei, Chan Chia-Hsin
机构信息
Department of Pharmacological Sciences, Stony Brook University, Stony Brook, NY, USA.
Stony Brook Cancer Center, Stony Brook University, Stony Brook, NY, USA.
出版信息
Mol Cell Oncol. 2019 Jul 24;6(5):e1644599. doi: 10.1080/23723556.2019.1644599. eCollection 2019.
Our study uncovered that HectH9 drives glycolysis and tumor development by K63-linked ubiquitination of Hexokinase 2 (HK2). This mechanism is critical for HK2 localization to mitochondria for activating HK2's functions in glycolysis promotion and apoptosis inhibition, suggesting that targeting HectH9 is a new strategy to tackle metabolism-addicted tumors.
我们的研究发现，HectH9通过对己糖激酶2（HK2）进行K63连接的泛素化来驱动糖酵解和肿瘤发展。这一机制对于HK2定位于线粒体以激活其促进糖酵解和抑制凋亡的功能至关重要，这表明靶向HectH9是应对代谢成瘾性肿瘤的一种新策略。
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