Cao Liangzi, Liu Xiaofang, Zheng Bowen, Xing Chengzhong, Liu Jingwei
Department of Anus and Intestine Surgery, First Affiliated Hospital of China Medical University, Shenyang, Liaoning Province, China.
Cell Death Discov. 2022 Oct 6;8(1):410. doi: 10.1038/s41420-022-01204-0.
Ubiquitination is a critical type of post-translational modifications, of which K63-linked ubiquitination regulates interaction, translocation, and activation of proteins. In recent years, emerging evidence suggest involvement of K63-linked ubiquitination in multiple signaling pathways and various human diseases including cancer. Increasing number of studies indicated that K63-linked ubiquitination controls initiation, development, invasion, metastasis, and therapy of diverse cancers. Here, we summarized molecular mechanisms of K63-linked ubiquitination dictating different biological activities of tumor and highlighted novel opportunities for future therapy targeting certain regulation of K63-linked ubiquitination in tumor.
泛素化是一种关键的翻译后修饰类型，其中K63连接的泛素化调节蛋白质的相互作用、易位和激活。近年来，新出现的证据表明K63连接的泛素化参与多种信号通路以及包括癌症在内的各种人类疾病。越来越多的研究表明，K63连接的泛素化控制着多种癌症的起始、发展、侵袭、转移和治疗。在此，我们总结了K63连接的泛素化决定肿瘤不同生物学活性的分子机制，并强调了未来针对肿瘤中K63连接泛素化的特定调控进行治疗的新机会。
