School of Chemical Science and Engineering , Tongji University , 1239 Siping Road , Shanghai 200092 , China.
School of Materials Science and Engineering , Liaocheng University , Liaocheng 252059 , China.
Anal Chem. 2019 Oct 15;91(20):13183-13190. doi: 10.1021/acs.analchem.9b03534. Epub 2019 Sep 24.
The nitrogen-containing imine or hydrazone linked covalent organic frameworks (COFs) are poorly luminescent due to the fluorescence quenching by nitrogen atoms in the linkages, even if highly luminescent units and linkers are employed. The fluorescence quenching pathway to prevent linkage-originated to mitigate the inherent limitations of the linkage is a promising method for luminescent COFs. The generation of N by deprotonation of the N-H unit eliminates the electron transfer from N lone pair to COF () and enhances the luminescence. In this work, achieved turn-on luminescence response with good sensitivity and reproducibility toward triethylamine (TEA) vapor in the process of deprotonation. The fabricated detector offers a viable approach for sensing ppm-level TEA, which can remind people to take timely measures to reduce the environmental hazards caused by TEA. The fluorescent sensor constructed by the products of and TEA can quantitatively trace biomarker methylglyoxal (MGO) for diabetes mellitus diagnosis in serum system. Furthermore, using TEA and MGO as input signals and the two fluorescence emissions G476 and Y525 as output signals, an advanced analytical device based on two Boolean logic gates with INH and AND function is constructed. This work provides a new strategy for improving the weak luminescence of COF in aqueous solution and realizes selective response to biomarker (MGO) for diabetes mellitus diagnosis.
含氮亚胺或腙键合共价有机骨架（COFs）由于连接物中的氮原子荧光猝灭，即使使用高度发光的单元和连接物，其发光也很差。防止由连接引起的荧光猝灭的途径以减轻连接的固有局限性是改善发光 COFs 的有前途的方法。通过 N-H 单元的去质子化生成 N，消除了从 N 孤对到 COF（）的电子转移，并增强了发光。在这项工作中，通过去质子化过程，实现了对三乙胺（TEA）蒸气的开启式发光响应，具有良好的灵敏度和重现性。所制备的探测器为检测 ppm 级 TEA 提供了一种可行的方法，可以提醒人们及时采取措施，减少 TEA 造成的环境危害。由和 TEA 的产物构建的荧光传感器可以定量追踪血清系统中糖尿病的生物标志物甲基乙二醛（MGO）。此外，使用 TEA 和 MGO 作为输入信号以及两个荧光发射 G476 和 Y525 作为输出信号，构建了一种基于具有 INH 和 AND 功能的两个布尔逻辑门的先进分析装置。这项工作为提高 COF 在水溶液中的弱发光提供了一种新策略，并实现了对糖尿病生物标志物（MGO）的选择性响应。
