Kaido Minako, Kawashima Motoko, Shigeno Yuta, Yamada Yoshiaki, Tsubota Kazuo
Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan.
Shinanozaka Clinic, Tokyo, Japan.
PLoS One. 2017 Sep 8;12(9):e0184296. doi: 10.1371/journal.pone.0184296. eCollection 2017.
To investigate accommodative microfluctuations (AMFs) and visual function in short tear break-up time (BUT)-type dry eye (DE) and non-DE subjects.
This prospective comparative study included 48 volunteers with DE symptoms (mean age 34.8 ± 5.5 years, age range 25-42 years) and 73 without DE symptoms (mean age 30.6 ± 4.7 years, age range 25-42 years). The eyes were divided into two groups: (1) DE group with DE symptoms and BUT ≤ 5 s and (2) non-DE group without DE symptoms and BUT > 5 s. We excluded eyes with Schirmer score ≤ 5 mm and positive keratoconjunctival epithelial damage. Tear evaluation, AMF, and functional visual acuity (VA) examinations were performed. AMF parameters included total high-frequency component (HFC), HFC with low accommodation for the task of staring into the distance (HFC1), and HFC with high accommodation for deskwork (HFC2). Functional VA parameters included starting VA, functional VA, visual maintenance ratio, and blink frequency.
A total of 33 and 34 eyes were categorized in the DE and non-DE groups, respectively. Mean blink frequency and HFC1 values were significantly higher in the DE group than they were in the non-DE group.
DEs with symptoms showed abnormal AMF and visual function, which may be associated with DE symptoms.
研究短泪膜破裂时间（BUT）型干眼（DE）和非干眼受试者的调节性微波动（AMF）及视觉功能。
这项前瞻性对照研究纳入了48名有干眼症状的志愿者（平均年龄34.8±5.5岁，年龄范围25 - 42岁）和73名无干眼症状的志愿者（平均年龄30.6±4.7岁，年龄范围25 - 42岁）。将眼睛分为两组：（1）有干眼症状且BUT≤5秒的干眼组；（2）无干眼症状且BUT>5秒的非干眼组。我们排除了泪液分泌试验评分≤5毫米且角膜结膜上皮损伤阳性的眼睛。进行了泪液评估、AMF和功能性视力（VA）检查。AMF参数包括总高频成分（HFC）、凝视远方任务时低调节的HFC（HFC1）以及近距离工作时高调节的HFC（HFC2）。功能性VA参数包括起始视力、功能性视力、视觉维持率和眨眼频率。
干眼组和非干眼组分别有33只和34只眼睛。干眼组的平均眨眼频率和HFC1值显著高于非干眼组。
有症状的干眼患者表现出异常的AMF和视觉功能，这可能与干眼症状有关。
