Department of Ophthalmology, Keio University School of Medicine, Shinanomachi 35, Shinnjuku-ku, Tokyo, Japan.
The Johnson & Johnson Ocular Surface Visual Optics Department, Keio University School of Medicine, Tokyo, Japan.
Jpn J Ophthalmol. 2011 Sep;55(5):451-459. doi: 10.1007/s10384-011-0049-8. Epub 2011 Jun 30.
To investigate the relation of functional visual acuity (FVA) measurements with dry eye test parameters and to compare the testing methods with and without blink suppression and anesthetic instillation.
A prospective comparative case series.
Thirty right eyes of 30 dry eye patients and 25 right eyes of 25 normal subjects seen at Keio University School of Medicine, Department of Ophthalmology were studied. FVA testing was performed using a FVA measurement system with two different approaches, one in which measurements were made under natural blinking conditions without topical anesthesia (FVA-N) and the other in which the measurements were made under the blink suppression condition with topical anesthetic eye drops (FVA-BS). Tear function examinations, such as the Schirmer test, tear film break-up time, and fluorescein and Rose Bengal vital staining as ocular surface evaluation, were performed.
The mean logMAR FVA-N scores and logMAR Landolt visual acuity scores were significantly lower in the dry eye subjects than in the healthy controls (p < 0.05), while there were no statistical differences between the logMAR FVA-BS scores of the dry eye subjects and those of the healthy controls. There was a significant correlation between the logMAR Landolt visual acuities and the logMAR FVA-N and logMAR FVA-BS scores. The FVA-N scores correlated significantly with tear quantities, tear stability and, especially, the ocular surface vital staining scores.
FVA measurements performed under natural blinking significantly reflected the tear functions and ocular surface status of the eye and would appear to be a reliable method of FVA testing. FVA measurement is also an accurate predictor of dry eye status.
探讨功能性视力（FVA）测量与干眼测试参数的关系，并比较有/无眨眼抑制和麻醉滴眼情况下的测试方法。
前瞻性对照病例系列。
本研究纳入了来自庆应义塾大学医学院眼科的 30 例干眼患者的 30 只右眼和 25 例正常对照者的 25 只右眼。使用具有两种不同方法的 FVA 测量系统进行 FVA 测试，一种是在不使用局部麻醉的自然眨眼条件下进行的测量（FVA-N），另一种是在眨眼抑制条件下使用局部麻醉滴眼剂进行的测量（FVA-BS）。进行了泪液功能检查，如 Schirmer 测试、泪膜破裂时间以及荧光素和玫瑰红 Bengal 染色等眼表面评估。
干眼患者的平均 logMAR FVA-N 评分和 logMAR Landolt 视力评分明显低于健康对照组（p<0.05），而干眼患者的 logMAR FVA-BS 评分与健康对照组之间无统计学差异。logMAR Landolt 视力与 logMAR FVA-N 和 logMAR FVA-BS 评分之间存在显著相关性。FVA-N 评分与泪液量、泪液稳定性以及特别是眼表面活力染色评分显著相关。
在自然眨眼条件下进行的 FVA 测量显著反映了眼睛的泪液功能和眼表面状况，似乎是一种可靠的 FVA 测试方法。FVA 测量也是干眼状态的准确预测指标。
