• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

1例伴有干燥综合征的顽固性急性泛发性脓疱病：采用低剂量环孢素成功治疗

A case of recalcitrant acute generalized exanthematous pustulosis with Sjogren's syndrome: Successfully treated with low-dose cyclosporine.

作者信息

İslamoğlu Zeynep Gizem Kaya, Karabağli Pınar

机构信息

Department of Dermatology, Faculty of Medicine Selcuk University Konya Turkey.

Department of Pathology, Faculty of Medicine Selcuk University Konya Turkey.

出版信息

Clin Case Rep. 2019 Aug 4;7(9):1721-1724. doi: 10.1002/ccr3.2352. eCollection 2019 Sep.

DOI:10.1002/ccr3.2352
PMID:31534735
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6745342/
Abstract

Acute generalized exanthematous pustulosis (AGEP) is a reaction attributed mainly to drugs. Hydroxychloroquine is a rare cause of AGEP especially used in rheumatology and dermatology. Systemic corticosteroids are the first-line treatment agents in AGEP. But cyclosporine can be a good choice for patients resistant to systemic corticosteroid treatment in AGEP.

摘要

急性泛发性脓疱性皮病（AGEP）主要是一种由药物引起的反应。羟氯喹是AGEP的罕见病因，尤其在风湿病学和皮肤病学中使用。全身性皮质类固醇是AGEP的一线治疗药物。但环孢素对于AGEP中对全身性皮质类固醇治疗耐药的患者可能是一个不错的选择。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/857c/6745342/8f598f6b2eb1/CCR3-7-1721-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/857c/6745342/02198a4f8014/CCR3-7-1721-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/857c/6745342/e16533f4f917/CCR3-7-1721-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/857c/6745342/0e3cec6991c8/CCR3-7-1721-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/857c/6745342/9b94f05e8acd/CCR3-7-1721-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/857c/6745342/8f598f6b2eb1/CCR3-7-1721-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/857c/6745342/02198a4f8014/CCR3-7-1721-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/857c/6745342/e16533f4f917/CCR3-7-1721-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/857c/6745342/0e3cec6991c8/CCR3-7-1721-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/857c/6745342/9b94f05e8acd/CCR3-7-1721-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/857c/6745342/8f598f6b2eb1/CCR3-7-1721-g005.jpg

相似文献

1
A case of recalcitrant acute generalized exanthematous pustulosis with Sjogren's syndrome: Successfully treated with low-dose cyclosporine.1例伴有干燥综合征的顽固性急性泛发性脓疱病：采用低剂量环孢素成功治疗
Clin Case Rep. 2019 Aug 4;7(9):1721-1724. doi: 10.1002/ccr3.2352. eCollection 2019 Sep.
2
Successful Treatment of Hydroxychloroquine-Induced Recalcitrant Acute Generalized Exanthematous Pustulosis with Cyclosporine: Case Report and Literature Review.环孢素成功治疗羟氯喹诱导的顽固性急性泛发性脓疱性皮病：病例报告及文献综述
Ann Dermatol. 2015 Aug;27(4):431-4. doi: 10.5021/ad.2015.27.4.431. Epub 2015 Jul 29.
3
The First Pediatric Case of Acute Generalized Exanthematous Pustulosis Caused by Hydroxychloroquine.羟氯喹致急性泛发性发疹性脓疱病的首例儿科病例报告。
Pharmacology. 2019;104(1-2):57-59. doi: 10.1159/000500406. Epub 2019 May 8.
4
Clinical presentation and management of atypical and recalcitrant acute generalized exanthematous pustulosis.不典型和难治性急性泛发性发疹性脓疱病的临床表现和治疗。
J Am Acad Dermatol. 2022 Sep;87(3):632-639. doi: 10.1016/j.jaad.2020.09.024. Epub 2020 Sep 11.
5
Cyclosporine for corticosteroid-refractory acute generalized exanthematous pustulosis due to hydroxychloroquine.环孢素治疗羟氯喹致皮质类固醇激素耐药性急性泛发性发疹性脓疱病。
Dermatol Ther. 2018 Sep;31(5):e12660. doi: 10.1111/dth.12660. Epub 2018 Aug 28.
6
Acute generalized exanthematous pustulosis induced by hydroxychloroquine: three cases and a review of the literature.羟氯喹诱导的急性泛发性脓疱性皮病：三例报告并文献复习
Clin Ther. 2008 May;30(5):930-40. doi: 10.1016/j.clinthera.2008.05.014.
7
Prolonged pustular eruption from hydroxychloroquine: an unusual case of acute generalized exanthematous pustulosis.羟氯喹引起的持续性脓疱疹：一例罕见的急性泛发性脓疱性皮病病例
Cutis. 2016 Mar;97(3):212-6.
8
Terbinafine Induced Acute Generalized Exanthematous Pustulosis Treated with Adalimumab: Recalcitrant to Systemic Corticosteroid Therapy.阿达木单抗治疗特比萘芬诱发的急性泛发性脓疱性银屑病：对全身皮质类固醇治疗无效。
Clin Cosmet Investig Dermatol. 2023 Jan 4;16:9-15. doi: 10.2147/CCID.S391979. eCollection 2023.
9
Acute generalized exanthematous pustulosis and Stevens-Johnson syndrome overlap due to hydroxychloroquine: a case report.羟氯喹引发急性泛发性脓疱性皮病与史蒂文斯-约翰逊综合征重叠：一例报告
J Med Case Rep. 2020 Nov 3;14(1):210. doi: 10.1186/s13256-020-02504-8.
10
Clinical features of acute generalized exanthematous pustulosis caused by hydroxychloroquine in rheumatology patients and exploration of gene mutations.风湿科患者中由羟氯喹引起的急性泛发性脓疱性皮病的临床特征及基因突变探索
Front Med (Lausanne). 2023 Apr 6;10:1161837. doi: 10.3389/fmed.2023.1161837. eCollection 2023.

引用本文的文献

1
Unusual Presentation of Acute Generalized Exanthematous Pustulosis with Unilateral Anterior Trunk Involvement.急性泛发性脓疱性皮病单侧前躯干受累的不寻常表现。
Sisli Etfal Hastan Tip Bul. 2024 Dec 24;58(4):518-520. doi: 10.14744/SEMB.2024.57431. eCollection 2024.
2
Clinical features of acute generalized exanthematous pustulosis caused by hydroxychloroquine in rheumatology patients and exploration of gene mutations.风湿科患者中由羟氯喹引起的急性泛发性脓疱性皮病的临床特征及基因突变探索
Front Med (Lausanne). 2023 Apr 6;10:1161837. doi: 10.3389/fmed.2023.1161837. eCollection 2023.
3
Terbinafine Induced Acute Generalized Exanthematous Pustulosis Treated with Adalimumab: Recalcitrant to Systemic Corticosteroid Therapy.

本文引用的文献

1
The First Pediatric Case of Acute Generalized Exanthematous Pustulosis Caused by Hydroxychloroquine.羟氯喹致急性泛发性发疹性脓疱病的首例儿科病例报告。
Pharmacology. 2019;104(1-2):57-59. doi: 10.1159/000500406. Epub 2019 May 8.
2
AGEP overlap induced by hydroxychloroquine: a case report and literature review.羟氯喹引发的中毒性表皮坏死松解症重叠综合征：一例报告及文献综述
J Community Hosp Intern Med Perspect. 2018 Dec 11;8(6):360-362. doi: 10.1080/20009666.2018.1547089. eCollection 2018.
3
Cyclosporine for corticosteroid-refractory acute generalized exanthematous pustulosis due to hydroxychloroquine.
阿达木单抗治疗特比萘芬诱发的急性泛发性脓疱性银屑病：对全身皮质类固醇治疗无效。
Clin Cosmet Investig Dermatol. 2023 Jan 4;16:9-15. doi: 10.2147/CCID.S391979. eCollection 2023.
4
Drug Triggers and Clinic of Acute Generalized Exanthematous Pustulosis (AGEP): A Literature Case Series of 297 Patients.药物引发的急性泛发性脓疱性皮病（AGEP）及其临床研究：297例患者的文献病例系列
J Clin Med. 2022 Jan 13;11(2):397. doi: 10.3390/jcm11020397.
5
Acute generalized exanthematous pustulosis with a focus on hydroxychloroquine: A 10-year experience in a skin hospital.急性泛发性发疹性脓疱病，重点关注羟氯喹：一家皮肤医院的 10 年经验。
Int Immunopharmacol. 2020 Dec;89(Pt B):107093. doi: 10.1016/j.intimp.2020.107093. Epub 2020 Oct 19.
6
Acute generalized exanthematous pustulosis induced by hydroxychloroquine prescribed for COVID-19.用于治疗新冠肺炎的羟氯喹引发的急性泛发性脓疱性皮病
J Allergy Clin Immunol Pract. 2020 Sep;8(8):2777-2779.e1. doi: 10.1016/j.jaip.2020.05.046. Epub 2020 Jun 7.
7
Generalized pustular figurate erythema: A newly delineated severe cutaneous drug reaction linked with hydroxychloroquine.泛发性脓疱状图状红斑：一种与羟氯喹相关的新划定的严重皮肤药物反应。
Dermatol Ther. 2020 May;33(3):e13380. doi: 10.1111/dth.13380. Epub 2020 Apr 16.
环孢素治疗羟氯喹致皮质类固醇激素耐药性急性泛发性发疹性脓疱病。
Dermatol Ther. 2018 Sep;31(5):e12660. doi: 10.1111/dth.12660. Epub 2018 Aug 28.
4
Severe cutaneous adverse reactions to drugs.药物严重皮肤不良反应。
Lancet. 2017 Oct 28;390(10106):1996-2011. doi: 10.1016/S0140-6736(16)30378-6. Epub 2017 May 2.
5
Acute generalized exanthematous pustulosis (AGEP): A review and update.急性泛发性发疹性脓疱病（AGEP）：综述与更新。
J Am Acad Dermatol. 2015 Nov;73(5):843-8. doi: 10.1016/j.jaad.2015.07.017. Epub 2015 Sep 6.
6
Successful Treatment of Hydroxychloroquine-Induced Recalcitrant Acute Generalized Exanthematous Pustulosis with Cyclosporine: Case Report and Literature Review.环孢素成功治疗羟氯喹诱导的顽固性急性泛发性脓疱性皮病：病例报告及文献综述
Ann Dermatol. 2015 Aug;27(4):431-4. doi: 10.5021/ad.2015.27.4.431. Epub 2015 Jul 29.
7
Rapid clearing of acute generalized exanthematous pustulosis after administration of ciclosporin.环孢素治疗后急性泛发性发疹性脓疱病迅速消退。
Clin Exp Dermatol. 2009 Dec;34(8):e757-9. doi: 10.1111/j.1365-2230.2009.03480.x. Epub 2009 Jul 29.
8
Risk factors for acute generalized exanthematous pustulosis (AGEP)-results of a multinational case-control study (EuroSCAR).急性泛发性脓疱性皮病（AGEP）的危险因素——一项多国病例对照研究（欧洲严重不良皮肤反应协作网研究）的结果
Br J Dermatol. 2007 Nov;157(5):989-96. doi: 10.1111/j.1365-2133.2007.08156.x. Epub 2007 Sep 13.
9
Clinical heterogeneity of drug hypersensitivity.药物超敏反应的临床异质性。
Toxicology. 2005 Apr 15;209(2):123-9. doi: 10.1016/j.tox.2004.12.022.
10
[Acute generalized exanthematic pustuloses (four cases) (author's transl)].急性泛发性脓疱性皮病（4例）（作者译）
Ann Dermatol Venereol. 1980 Jan-Feb;107(1-2):37-48.