溶组织内阿米巴提取物对小鼠淋巴细胞的促有丝分裂活性。
Mitogenicity of Entamoeba histolytica extracts for murine lymphocytes.
作者信息
Diamantstein T, Trissl D, Klos M, Gold D, Hahn H
出版信息
Immunology. 1980 Oct;41(2):347-52.
Abstract
Aqueous extracts or aqueous extracts of delipidated Entamoeba histolytica (E.h.e.) contain a mitogenic principle for murine lymphocytes. As detected by [3H]-thymidine incorporation and blast transformation, E.h.e. acted predominantly on T cells of splenic origin, but not on thymocytes or bone marrow cells. Furthermore, E.h.e. induced proliferation of a subset of non-T-cells which is present in the spleen of athymic nude mice, adhered to nylon wool, but could not be activated to produce antibody. It seems possible that polyclonal activation of lymphocytes by E. histolytica might play a role in the disturbance of the immune system as manifested in the impaired cell mediated immune response of E. histolytica infected hosts.
摘要
去脂溶组织内阿米巴的水提取物（E.h.e.）含有一种对鼠淋巴细胞有促有丝分裂作用的物质。通过[3H] - 胸腺嘧啶核苷掺入和母细胞转化检测发现，E.h.e.主要作用于脾源性T细胞，而不作用于胸腺细胞或骨髓细胞。此外，E.h.e.诱导了无胸腺裸鼠脾脏中存在的一部分非T细胞的增殖，这些细胞能黏附于尼龙毛，但不能被激活产生抗体。溶组织内阿米巴对淋巴细胞的多克隆激活可能在免疫系统紊乱中起作用，这在溶组织内阿米巴感染宿主的细胞介导免疫反应受损中表现出来。
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