卡介苗治疗后对脾细胞体外反应性的主动抑制。
Active suppression of in vitro reactivity of spleen cells after BCG treatment.
作者信息
Orbach-Arbouys S, Poupon M F
出版信息
Immunology. 1978 Mar;34(3):431-7.
Abstract
It was found that spleen cells from mice injected i.v. with large doses of BCG respond to PHA stimulation less intensely than do normal spleen cells. We were able to show that nylon wool column purified BCG treated T cells also had a low PHA reactivity. Unfractionated spleen cells, adherent cells or T-enriched populations from BCG treated mice, when added to normal T cells lowered their PHA reactivity. When the same BCG treated cell populations were added to tumor cells in vitro, they inhibited their growth.
摘要
结果发现，经静脉注射大剂量卡介苗的小鼠的脾细胞对PHA刺激的反应不如正常脾细胞强烈。我们能够证明，经尼龙毛柱纯化的卡介苗处理的T细胞对PHA的反应性也很低。来自卡介苗处理小鼠的未分离脾细胞、贴壁细胞或富含T细胞的群体，当添加到正常T细胞中时，会降低它们对PHA的反应性。当将相同的卡介苗处理的细胞群体在体外添加到肿瘤细胞中时，它们会抑制肿瘤细胞的生长。
相似文献
1
Active suppression of in vitro reactivity of spleen cells after BCG treatment.
Immunology. 1978 Mar;34(3):431-7.
2
[Spleen reactivity after BCG treatement: test and strain dependency of the response].
Ann Immunol (Paris). 1977 Jan-Mar;128(1-2):271-2.
3
Study of the effect of single or multiple doses of BCG on antibody-dependent cellular cytotoxicity.
Immunology. 1980 Nov;41(3):687-94.
4
5
Augmentation of immune responses after methotrexate administration.
Immunology. 1979 Feb;36(2):265-9.
6
Is the adherent, non-specific 'suppressor' cell from rodent spleens an in vitro artefact?
Clin Exp Immunol. 1978 Jun;32(3):466-70.
7
Induction or suppression of B cell proliferation and differentiation by phytohemagglutinin or concanavalin A in mouse spleen cell cultures.
J Immunol. 1976 Nov;117(5 Pt.2):1817-23.
8
9
Lymphocyte-macrophage interactions in BCG-treated mice.
Recent Results Cancer Res. 1976(56):49-57. doi: 10.1007/978-3-642-81049-7_7.
10
Regulatory action of THF on T-cell reactivity to mitogens.
Thymus. 1980 Jan;1(4-5):225-39.
引用本文的文献
1
Modulation of mitogenic responsiveness by staphylococcal peptidoglycan.
Infect Immun. 1980 Nov;30(2):431-8. doi: 10.1128/iai.30.2.431-438.1980.
2
Bacillus Calmette-Guérin (BCG) decreases resistance to Listeria monocytogenes infection in mice.
Immunology. 1981 Nov;44(3):509-15.
3
Immune response to atypical mycobacteria: immunocompetence of heavily infected mice measured in vivo fails to substantiate immunosuppression data obtained in vitro.
Infect Immun. 1984 Jan;43(1):32-7. doi: 10.1128/iai.43.1.32-37.1984.
4
The immunologic and immunotherapeutic sequelae of intraperitoneal BCG. II: Serial changes in spleen weight, morphology, cell populations and in vitro mitogen responses.
Ir J Med Sci. 1983 Aug;152(8):307-10. doi: 10.1007/BF02945303.
5
Production of a suppressor factor by adherent cells from Mycobacterium tuberculosis-infected guinea-pigs.
Clin Exp Immunol. 1981 Aug;45(2):427-32.
6
Evidence for two distinct populations of suppressor cells in the spleens of Mycobacterium bovis BCG-Sensitized mice.
Infect Immun. 1981 Nov;34(2):315-22. doi: 10.1128/iai.34.2.315-322.1981.
7
Development of suppressor T cells in mice heavily infected with mycobacteria.
Immunology. 1980 Mar;39(3):367-73.
8
Active suppression masks an underlying enhancement of antibody production in vitro by spleen cells from BCG-infected mice.
Immunology. 1980 Jul;40(3):303-9.
9
Suppression of T-cell responses to histocompatibility antigens by BCG pre-treatment.
Immunology. 1980 Feb;39(2):263-8.
本文引用的文献
1
The modifying effect of BCG on the immunological induction of T cells.
J Exp Med. 1974 Jun 1;139(6):1540-52. doi: 10.1084/jem.139.6.1540.
2
A rapid method for the isolation of functional thymus-derived murine lymphocytes.
Eur J Immunol. 1973 Oct;3(10):645-9. doi: 10.1002/eji.1830031011.
3
Immunopotentiation with BCG. II. Modulation of the response to sheep red blood cells.
J Natl Cancer Inst. 1973 Nov;51(5):1669-76. doi: 10.1093/jnci/51.5.1669.
4
On the mode of action of BCG.
Nat New Biol. 1973 Jun 13;243(128):216-8. doi: 10.1038/newbio243216a0.
5
Active immunotherapy for acute lymphoblastic leukaemia.
Lancet. 1969 Apr 5;1(7597):697-9. doi: 10.1016/s0140-6736(69)92648-8.
6
Splenic suppressor macrophages induced in mice by injection of Corynebacterium parvum.
J Immunol. 1975 Nov;115(5):1212-6.
7
Specific and nonspecific antitumor immunity. II. Macrophage-mediated nonspecific effector activity induced by BCG and similar agents.
J Natl Cancer Inst. 1975 Mar;54(3):709-20.
8
Specific and nonspecific antitumor immunity. I. Description of an in vitro assay based on inhibition of DNA synthesis in tumor cells.
J Natl Cancer Inst. 1975 Mar;54(3):697-708.
9
Cytostatic effect of spleen cells of tumor-bearing mice on syngenetic tumor cells.
Cancer Res. 1977 Jun;37(6):1727-32.
10
Macrophage regulation of mitogen-induced blastogenesis. I. Demonstration of inhibitory cells in the spleens and peritoneal exudates of mice.
Cell Immunol. 1977 Jan;28(1):22-35. doi: 10.1016/s0008-8749(77)80003-8.
Zotero 插件