Jenabi Ensiyeh, Fereidooni Bita, Karami Manoochehr, Masoumi Seyedeh Zahra, Safari Mahdi, Khazaei Salman
Autism Spectrum Disorders Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
Midwife in Social Security Organization, Hamadan, Iran.
Obstet Gynecol Sci. 2019 Sep;62(5):352-356. doi: 10.5468/ogs.2019.62.5.352. Epub 2019 Jul 26.
Primary dysmenorrhea typically occurs with no associated pelvic pathology and is common in adolescents and young women. This study evaluated the effect of bee propolis on relief of primary dysmenorrhea.
The study was performed in 2018 in Hamadan, in western Iran, among female students with primary dysmenorrhea. Participants were randomly divided into two groups, using balanced block randomization, and were administered a placebo or bee propolis capsules for 5 days during two menstruation cycles. The number of participants required was estimated to be 86 in total, with 43 students in each group according to the inclusion criteria. We used the visual analog scale to assess pain severity. The independent -test was conducted for comparing between two groups, using SPSS 16.0.
A significant change was found in the mean pain scores during the first (<0.001) and second (<0.001) months after using bee propolis in comparison with placebo. The means of the pain scores in the bee propolis group were 5.32±2.28 and 4.74±2.40 in first and second months after the intervention, respectively, whereas the means of the pain scores in the placebo group were 7.40±1.21 and 7.17±1.24 in first and second months after the intervention, respectively.
Our study showed that the use of bee propolis for two months compared with placebo reduced primary dysmenorrhea during the first and second months after use, with no adverse effects. Therefore, it could be used as an alternative to nonsteroidal anti-inflammatory drugs for relief of primary dysmenorrhea.
原发性痛经通常在无相关盆腔病变的情况下发生，在青少年和年轻女性中很常见。本研究评估了蜂胶对缓解原发性痛经的效果。
该研究于2018年在伊朗西部的哈马丹对患有原发性痛经的女学生进行。参与者采用均衡区组随机化方法随机分为两组，并在两个月经周期内服用安慰剂或蜂胶胶囊5天。根据纳入标准，估计总共需要86名参与者，每组43名学生。我们使用视觉模拟量表评估疼痛严重程度。使用SPSS 16.0进行独立样本t检验以比较两组之间的差异。
与安慰剂相比，使用蜂胶后的第一个月（<0.001）和第二个月（<0.001）平均疼痛评分有显著变化。干预后第一个月和第二个月，蜂胶组疼痛评分的均值分别为5.32±2.28和4.74±2.40，而安慰剂组干预后第一个月和第二个月疼痛评分的均值分别为7.40±1.21和7.17±1.24。
我们的研究表明，与安慰剂相比，使用蜂胶两个月可在使用后的第一个月和第二个月减轻原发性痛经，且无不良反应。因此，它可作为非甾体抗炎药缓解原发性痛经的替代药物。
