通过实验和计算方法对 Dictyospiromide 的表征，一种来自海洋藻类的有趣抗氧化生物碱。
Characterization by Empirical and Computational Methods of Dictyospiromide, an Intriguing Antioxidant Alkaloid from the Marine Alga .
机构信息
School of Pharmaceutical Sciences , Wenzhou Medical University , Wenzhou , Zhejiang 325035 , People's Republic of China.
Institute of Oceanology , Chinese Academy of Sciences , Qingdao 266071 , People's Republic of China.
出版信息
Org Lett. 2019 Sep 20;21(18):7577-7581. doi: 10.1021/acs.orglett.9b02856. Epub 2019 Sep 6.
Abstract
The challenging structural motif of dictyospiromide (), a spirosuccinimide alkaloid with antioxidant properties that are associated with activation of the Nrf2/ARE signaling pathway, was assigned using contemporary NMR experiments complemented with anisotropic NMR, chiroptical, and computational methodologies. Anisotropic NMR parameters provided critical orthogonal verification of the configuration of the difficult to assign spiro carbon and the other stereogenic centers in .
摘要
具有抗氧化特性的二氢螺旋霉素（）是一种螺旋缩肽生物碱，其抗氧化特性与 Nrf2/ARE 信号通路的激活有关，其具有挑战性的结构模体是通过使用当代 NMR 实验辅以各向异性 NMR、手性光学和计算方法来确定的。各向异性 NMR 参数提供了对难以分配的螺旋碳和其他立体中心的配置的关键正交验证。
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