Qi Yu, Liu Ge, Fang Chengyan, Jing Chengcheng, Tang Shuhua, Li Ge, Wang Chaojie, Zhu Haoru, Zhao Min, Sun Zhongmin, Wu Jianzhang, Yan Pengcheng
School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, People's Republic of China.
Department of Pharmacy, Shaoxing Hospital of Traditional Chinese Medicine, Shaoxing, Zhejiang 312000, People's Republic of China.
ACS Omega. 2023 Feb 16;8(8):8034-8044. doi: 10.1021/acsomega.2c07891. eCollection 2023 Feb 28.
Five new xenicane diterpenes, including three rare nitrogen-containing derivatives, dictyolactams A () and B () and 9-demethoxy-9-ethoxyjoalin (), a rare diterpene with a cyclobutanone moiety, named 4-hydroxyisoacetylcoriacenone (), and 19--acetyldictyodiol (), were isolated from an East China Sea collection of the brown alga , along with 15 known analogues (-). The structures of the new diterpenes were elucidated by spectroscopic analyses and theoretical ECD calculations. All compounds had cytoprotective effects against oxidative stress in neuron-like PC12 cells. The antioxidant mechanism of 18-acetoxy-6,7-epoxy-4-hydroxydictyo-19-al () was related to the activation of Nrf2/ARE signaling pathway; it also showed significant neuroprotective effects against cerebral ischemia-reperfusion injury (CIRI) . This study provided xenicane diterpene as a promising lead scaffold for the development of potent neuroprotective agents against CIRI.
从中国东海采集的褐藻中分离出5种新的异海松烷二萜，包括3种罕见的含氮衍生物，即网地藻内酰胺A（）和B（）以及9-去甲氧基-9-乙氧基乔阿林（），一种带有环丁酮部分的罕见二萜，命名为4-羟基异乙酰基科里亚酮（），还有19--乙酰基网地藻二醇（），以及15种已知类似物（-）。通过光谱分析和理论ECD计算阐明了新二萜的结构。所有化合物对神经元样PC12细胞的氧化应激均具有细胞保护作用。18-乙酰氧基-6,7-环氧-4-羟基网地藻-19-醛（）的抗氧化机制与Nrf2/ARE信号通路的激活有关；它对脑缺血再灌注损伤（CIRI）也显示出显著的神经保护作用。本研究提供了异海松烷二萜作为开发抗CIRI有效神经保护剂的有前景的先导骨架。
