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体外评价 Boiss. 亚种（Borbas）的抗氧化、抗炎、抗菌和伤口愈合潜力。

In Vitro Evaluation of Antioxidant, Anti-Inflammatory, Antimicrobial and Wound Healing Potential of Boiss. Subsp. (Borbas) .

机构信息

Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Istanbul University-Cerrahpasa, Avcilar, 34320 Istanbul, Turkey.

Department of Microbiology, Faculty of Veterinary Medicine, Istanbul University-Cerrahpasa, Avcilar, 34320 Istanbul, Turkey.

出版信息

Molecules. 2019 Sep 14;24(18):3353. doi: 10.3390/molecules24183353.

DOI:10.3390/molecules24183353
PMID:31540139
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6767006/
Abstract

Boiss. subsp. (Borbas) (TS) is a commonly used plant in the treatment of various complaints, including skin wounds in Turkish folk medicine. Despite the widespread traditional use of TS, there is not any scientific report confirming the effectiveness of this plant on the healing process. This research aimed to investigate the effects of different extracts obtained from TS on biological events during wound healing, on a cellular basis. In this context, proliferative activities of the extracts, as well as the effects on wound closure and hydroxyproline synthesis, were determined. In addition to wound healing properties, the antioxidant, antibacterial and anti-inflammatory activities of the extracts were evaluated. Decoction (D) and infusion (I) extracts contained the highest amount of phenolic content and showed the most potent activity against DPPH radical. All extracts exhibited complete protection against the damage induced by hydrogen peroxide (HO) by increasing cell viability compared to only HO-treated groups, both in co-treatment and pre-treatment protocols. None of the extracts exhibited cytotoxic activity, and most of the extracts from the TS stimulated fibroblast proliferation and migration. All TS extracts exert anti-inflammatory activity by suppressing the overproduction of tumor necrosis factor-alpha (TNF-α) and nitric oxide (NO). The most pronounced activity on hydroxyproline synthesis was observed in D extract. In summary, it was observed that TS extracts can promote the healing process by enhancing fibroblast migration, proliferation and collagen synthesis as well as suppressing pro-inflammatory cytokines. The obtained data in this work support the traditional use of TS as a valuable plant-based compound for the treatment of wounds.

摘要

Boiss. subsp. (Borbas) (TS) 是一种常用于治疗各种疾病的植物，包括土耳其民间医学中的皮肤创伤。尽管 TS 在传统上被广泛应用，但目前没有任何科学报告证实这种植物对愈合过程的有效性。本研究旨在从细胞基础上研究从 TS 获得的不同提取物对创伤愈合过程中生物事件的影响。在这方面，确定了提取物的增殖活性以及对伤口闭合和羟脯氨酸合成的影响。除了愈合伤口的特性外，还评估了提取物的抗氧化、抗菌和抗炎活性。浸膏 (D) 和汤剂 (I) 提取物含有最高量的酚类物质，对 DPPH 自由基的抑制作用最强。与仅用 HO 处理的组相比，所有提取物都通过增加细胞活力，在共处理和预处理方案中，对由过氧化氢 (HO) 诱导的损伤表现出完全的保护作用。所有提取物均无细胞毒性，TS 的大多数提取物均能刺激成纤维细胞增殖和迁移。所有 TS 提取物通过抑制肿瘤坏死因子-α (TNF-α) 和一氧化氮 (NO) 的过度产生来发挥抗炎作用。在羟脯氨酸合成方面，D 提取物表现出最显著的活性。总之，研究结果表明，TS 提取物可通过增强成纤维细胞迁移、增殖和胶原合成以及抑制促炎细胞因子来促进愈合过程。本工作中获得的数据支持将 TS 作为一种有价值的植物化合物用于治疗创伤的传统用途。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/35fa/6767006/3c3333058535/molecules-24-03353-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/35fa/6767006/4e20b98f7412/molecules-24-03353-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/35fa/6767006/386a617ca4d8/molecules-24-03353-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/35fa/6767006/74234a22a01c/molecules-24-03353-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/35fa/6767006/e544811f43be/molecules-24-03353-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/35fa/6767006/6d1fa1fbd7d9/molecules-24-03353-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/35fa/6767006/b277d7a0890d/molecules-24-03353-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/35fa/6767006/8a72945a2bdf/molecules-24-03353-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/35fa/6767006/540a0287f133/molecules-24-03353-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/35fa/6767006/3c3333058535/molecules-24-03353-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/35fa/6767006/4e20b98f7412/molecules-24-03353-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/35fa/6767006/386a617ca4d8/molecules-24-03353-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/35fa/6767006/74234a22a01c/molecules-24-03353-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/35fa/6767006/e544811f43be/molecules-24-03353-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/35fa/6767006/6d1fa1fbd7d9/molecules-24-03353-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/35fa/6767006/b277d7a0890d/molecules-24-03353-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/35fa/6767006/8a72945a2bdf/molecules-24-03353-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/35fa/6767006/540a0287f133/molecules-24-03353-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/35fa/6767006/3c3333058535/molecules-24-03353-g009.jpg

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