Reference Laboratory for Chikungunya and Dengue Viruses, Department of Virology, Centre Pasteur of Cameroon, Yaoundé, Cameroon.
Department of Biochemistry, Faculty of Sciences, University of Yaoundé I, Yaoundé, Cameroon.
Sci Rep. 2019 Sep 20;9(1):13626. doi: 10.1038/s41598-019-50135-x.
Better knowledge of the face of the current dengue virus (DENV) epidemiology in Africa can help to implement efficient strategies to curb the burden of dengue fever. We conducted this systematic review and meta-analysis to determine the prevalence of DENV infection in Africa. We searched PubMed, EMBASE, African Journals Online, and Africa Index Medicus from January 1, 2000 to June 10, 2019 without any language restriction. We used a random-effects model to pool studies. A total of 76 studies (80,977 participants; 24 countries) were included. No study had high risk of bias. Twenty-two (29%) had moderate and 54 (71%) had low risk of bias. In apparently healthy individuals, the pooled prevalence of DENV was 15.6% (95% confidence interval 9.9-22.2), 3.5% (0.8-7.8), and 0.0% (0.0-0.5) respectively for immunoglobulins (Ig) G, IgM, and for ribonucleic acid (RNA) in apparently healthy populations. In populations presenting with fever, the prevalence was 24.8% (13.8-37.8), 10.8% (3.8-20.6k) and 8.4% (3.7-14.4) for IgG, IgM, and for RNA respectively. There was heterogeneity in the distribution between different regions of Africa. The prevalence of DENV infection is high in the African continent. Dengue fever therefore deserves more attention from healthcare workers, researchers, and health policy makers.
更好地了解当前非洲登革热病毒 (DENV) 流行病学可以帮助实施有效的策略来遏制登革热的负担。我们进行了这项系统评价和荟萃分析，以确定非洲 DENV 感染的流行率。我们在 2000 年 1 月 1 日至 2019 年 6 月 10 日期间，在无任何语言限制的情况下，检索了 PubMed、EMBASE、African Journals Online 和 Africa Index Medicus。我们使用随机效应模型对研究进行了汇总。共有 76 项研究（80977 名参与者；24 个国家）被纳入。没有研究存在高偏倚风险。22 项（29%）研究存在中度偏倚，54 项（71%）研究存在低度偏倚。在看似健康的个体中，DENV 的总流行率分别为 IgG 为 15.6%（95%置信区间 9.9-22.2）、IgM 为 3.5%（0.8-7.8）和 RNA 为 0.0%（0.0-0.5），在看似健康人群中。在出现发热的人群中，流行率分别为 IgG 为 24.8%（13.8-37.8）、IgM 为 10.8%（3.8-20.6）和 RNA 为 8.4%（3.7-14.4）。非洲不同地区的分布存在异质性。非洲大陆 DENV 感染的流行率很高。因此，登革热值得医护人员、研究人员和卫生政策制定者给予更多关注。
