Kim G S, Bergfeld M A, Avioli L V, Teitelbaum S L
Korean J Intern Med. 1988 Jul;3(2):132-5. doi: 10.3904/kjim.1988.3.2.132.
A postmenopausal osteopenic woman presented with recurrent stress fractures of the feet and normal parameters of mineral homeostasis. Despite the absence of biochemical or radiographic evidence, severe osteomalacia was documented by histomorphometric analysis of a tetracycline labeled, non-decalcified bone biopsy. This observation underscores the need for specific bone biopsy confirmation of skeletal disease in patients with fracture-prone osteopenia.
一位绝经后骨质减少的女性出现足部反复应力性骨折，且矿物质稳态参数正常。尽管缺乏生化或影像学证据，但通过对四环素标记的未脱钙骨活检进行组织形态计量学分析，证实存在严重骨软化症。这一观察结果强调了对于易骨折的骨质减少患者，需要通过特定的骨活检来确诊骨骼疾病。
