Somteds Apisara, Tantapakul Cholpisut, Kanokmedhakul Kwanjai, Laphookhieo Surat, Phukhatmuen Piyaporn, Kanokmedhakul Somdej
Natural Products Research Unit, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen, Thailand.
Center of Chemical Innovation for Sustainability (CIS), School of Science, Mae Fah Luang University, Chiang Rai, Thailand.
Nat Prod Res. 2021 Aug;35(16):2722-2729. doi: 10.1080/14786419.2019.1667350. Epub 2019 Sep 23.
Chromatographic separation of crude extracts from the leaves and stems of Esser led to the isolation of two new clerodane diterpenes crotonolide K () and furocrotinsulolide A acetate () and six known clerodane diterpenes (), together with twelve known compounds (-). Their structures were established from spectroscopic analysis. The clerodane diterpenoids - were evaluated for inhibition of nitric oxide (NO) production in LPS-activated RAW 264.7 macrophages. Compounds , , , and showed potent inhibitory effects, with IC values ranging from 32.19 to 48.85 μM, which is better than both the standard drugs indomethacin (154.5 μM) and dexamethasone (56.28 μM).
对埃塞树（Esser）叶和茎的粗提物进行色谱分离，得到了两种新的克罗烷二萜巴豆内酯K（）和呋喃巴豆苏洛内酯A乙酸酯（）以及六种已知的克罗烷二萜（），还有十二种已知化合物（-）。通过光谱分析确定了它们的结构。对克罗烷二萜类化合物 - 进行了评估，以检测其对脂多糖激活的RAW 264.7巨噬细胞中一氧化氮（NO）产生的抑制作用。化合物 、 、 、 和 表现出强效抑制作用，IC值范围为32.19至48.85 μM，优于标准药物吲哚美辛（154.5 μM）和地塞米松（56.28 μM）。
