School of Advanced Agriculture and Bioengineering, Yangtze Normal University, Fuling 408100, Chongqing, China.
Molecules. 2019 Sep 19;24(18):3402. doi: 10.3390/molecules24183402.
Polymethylene-interrupted polyunsaturated fatty acids (PMI-PUFAs) are emerging functional lipids with proven antioxidant and anti-inflammatory effects. In this study, a typical PMI-PUFA, sciadonic acid (C20:3, 5c 11c 14c), was enriched in the kernel oil of () by fractionation. Fractionated kernel oil of (containing 25% sciadonic acid) showed equal stability and similar radical scavenging ability compared with the non-fractionated oil. In anti-inflammatory tests, fractionated kernel oil was shown to inhibit the activity of phosphodiesterase (PDE-5, efficiency 80% at 133.7 μg/mL) and lipoxygenase-5 (LOX-5, efficiency 65% at 66.7 μg/mL) more effectively than the non-fractionated oil. This shows that increasing the amount of sciadonic acid can enhance the anti-inflammatory effect of the kernel oil. This research also indicates that fractionation is a feasible way to obtain sciadonic acid-rich functional oil with potential pharmacological effects.
聚亚甲基中断的多不饱和脂肪酸 (PMI-PUFAs) 是一种新兴的功能性脂质，具有已证实的抗氧化和抗炎作用。在这项研究中，通过分级分离，在 （）的核仁油中富集了一种典型的 PMI-PUFA，即山桐子酸（C20:3, 5c 11c 14c）。（含有 25%山桐子酸）的分级核仁油与未分级油相比，具有相同的稳定性和相似的自由基清除能力。在抗炎测试中，分级核仁油显示出比未分级油更有效地抑制磷酸二酯酶（PDE-5，在 133.7 μg/mL 时效率为 80%）和脂氧合酶-5（LOX-5，在 66.7 μg/mL 时效率为 65%）的活性。这表明增加山桐子酸的含量可以增强核仁油的抗炎效果。这项研究还表明，分级是获得具有潜在药理作用的富含山桐子酸的功能性油的一种可行方法。
