Suruga Kohei, Tomita Tsuyoshi, Kadokura Kazunari, Arai Toshiro
Food Function R&D Division, International Operation Department, Kibun Foods Inc., Tokyo, Japan.
Laboratory of Veterinary Biochemistry, School of Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo, Japan.
Food Nutr Res. 2019 Sep 11;63. doi: 10.29219/fnr.v63.3601. eCollection 2019.
Obesity is a serious health problem in the world. We thought that the activity and safety of natural plants and/or foods are very important in the management of therapy for obesity. () is also known as lacquer tree in Japan and Korea, and it is consumed as food ingredients and/or traditional herbal medicine. We prepared an extract from leaves (Rv-PEM01-99) to develop a new functional food material and/or nutritional supplements.
This study evaluated the anti-obesity effects of the Rv-PEM01-99 in high-fat diet (HFD)-induced obese mice.
Six-week-old male C57BL/6J mice were divided into three groups: group I (HFD group), group II (HFD + 1% Rv-PEM01-99 group), and group III (HFD + 2% Rv-PEM01-99 group). Throughout the 56-day treatment period, body weights of these mice were checked twice a week. After 56 days, blood biochemical analyses were performed.
In animal studies, no death or abnormalities in food consumption were observed between groups I, II, and III. Body weight gain in the groups administered Rv-PEM01-99 was less than that in group I. In particular, body weight gain in group III was significantly less than that in group I after 52 days of Rv-PEM01-99 administration. In addition, intra-abdominal fat and leptin levels in group III were significantly lower than those in group I. HPLC and LC/MS analysis showed a quercetin derivative as an active compound in Rv-PEM01-99.
Rv-PEM01-99, containing a quercetin derivative, showed anti-obesity effect in HFD-fed mice. It could therefore be useful as food material and/or nutritional supplement for management of obesity.
肥胖是一个全球性的严重健康问题。我们认为天然植物和/或食物的活性及安全性在肥胖治疗管理中非常重要。（）在日本和韩国也被称为漆树，它被用作食品原料和/或传统草药。我们从（）叶中制备了一种提取物（Rv - PEM01 - 99），以开发一种新的功能性食品原料和/或营养补充剂。
本研究评估了Rv - PEM01 - 99对高脂饮食（HFD）诱导的肥胖小鼠的抗肥胖作用。
将6周龄雄性C57BL/6J小鼠分为三组：第一组（HFD组）、第二组（HFD + 1% Rv - PEM01 - 99组）和第三组（HFD + 2% Rv - PEM01 - 99组）。在整个56天的治疗期间，每周对这些小鼠的体重进行两次检查。56天后，进行血液生化分析。
在动物研究中，第一、二、三组之间未观察到死亡或食物消耗异常。给予Rv - PEM01 - 99的组体重增加少于第一组。特别是，在给予Rv - PEM01 - 99 52天后，第三组的体重增加明显少于第一组。此外，第三组的腹腔内脂肪和瘦素水平明显低于第一组。HPLC和LC/MS分析表明，槲皮素衍生物是Rv - PEM01 - 99中的活性化合物。
含有槲皮素衍生物的Rv - PEM01 - 99对高脂饮食喂养的小鼠具有抗肥胖作用。因此，它可用作管理肥胖的食品原料和/或营养补充剂。
