Packham D K, North R A, Fairley K F, Ihle B U, Whitworth J A, Kincaid-Smith P
Department of Nephrology, Royal Melbourne Hospital, Parkville, Victoria, Australia.
Clin Nephrol. 1988 Apr;29(4):185-92.
Thirty-one pregnancies and post partum clinical course of 21 women with a diagnosis of primary focal and segmental hyalinosis and sclerosis have been analyzed. Forty-five percent (14) of pregnancies resulted in fetal loss, 39% (12) in premature delivery and 16% (5) in a term infant. Of 17 fetuses for whom birthweight was recorded, 29% (5) were small for gestational age. Maternal renal function deteriorated in 49% (15) of pregnancies, in 13% (4) irreversibly. Three of these patients (15%) subsequently progressed to end-stage renal failure, and one to progressive chronic renal impairment, by the end of follow-up (median 4 years, range 1-25 years). In 74% (23) of pregnancies hypertension was recorded and this frequently developed early (61%) and was severe (45%). Nephrotic range proteinuria developed in 42% (13) of pregnancies. Increased proteinuria was recorded in 22 (17%) pregnancies. It is concluded that pregnancy in women with primary focal and segmental hyalinosis and sclerosis is associated with increased fetal loss and maternal complications.
对21例诊断为原发性局灶节段性玻璃样变性和硬化症的女性的31次妊娠及产后临床过程进行了分析。45%（14例）的妊娠导致胎儿丢失，39%（12例）早产，16%（5例）足月产。在记录了出生体重的17例胎儿中，29%（5例）小于胎龄。49%（15例）的妊娠中孕妇肾功能恶化，其中13%（4例）为不可逆恶化。随访结束时（中位时间4年，范围1 - 25年），这些患者中有3例（15%）进展为终末期肾衰竭，1例进展为进行性慢性肾功能损害。74%（23例）的妊娠记录有高血压，且高血压常较早出现（61%）且严重（45%）。42%（13例）的妊娠出现肾病范围蛋白尿。22例（17%）妊娠记录有蛋白尿增加。结论是，原发性局灶节段性玻璃样变性和硬化症女性的妊娠与胎儿丢失增加和母体并发症有关。
