Packham D K, North R A, Fairley K F, Whitworth J A, Lloren P R, Lee E, Kincaid-Smith P
Department of Nephrology, Royal Melbourne Hospital, Parkville, Victoria, Australia.
Clin Nephrol. 1988 Apr;29(4):193-8.
The clinical course of 168 pregnancies in 91 women with non-IgA diffuse mesangial proliferative glomerulonephritis has been analyzed. Twenty percent (33) of pregnancies resulted in fetal loss, 18% (31) in premature delivery and 62% (105) in a term infant. Maternal renal function declined, reversibly, in 3% (5) of pregnancies and in 48% (80) hypertension developed. In 53% (89) a significant increase in proteinuria occurred in pregnancy. Fetal and maternal complications of pregnancy occurred more frequently in patients with pre-existing hypertension although differences failed to reach statistical significance (p greater than 0.01). The presence of severe vessel lesions on the diagnostic renal biopsy was associated with a significantly higher fetal loss and prematurity rate (p less than 0.0005 and p less than 0.005, respectively).
对91例非IgA弥漫性系膜增生性肾小球肾炎女性患者的168次妊娠临床过程进行了分析。20%（33次）妊娠导致胎儿丢失，18%（31次）早产，62%（105次）足月产。3%（5次）妊娠中孕妇肾功能可逆性下降，48%（80次）发生高血压。53%（89次）妊娠中蛋白尿显著增加。既往有高血压的患者妊娠时胎儿和母亲并发症更常见，尽管差异未达到统计学意义（p>0.01）。诊断性肾活检显示存在严重血管病变与胎儿丢失率和早产率显著升高相关（分别为p<0.0005和p<0.005）。
