Organic Chemistry Division, Faculty of Mathematics and Natural Sciences, Institut Teknologi Bandung, Natural Product Research Group, Jalan Ganesha 10, Bandung, 40132, Indonesia.
Nat Prod Res. 2021 Jul;35(13):2274-2278. doi: 10.1080/14786419.2019.1667353. Epub 2019 Sep 26.
A new Diels-Alder type adduct named morushalunin (), together with three similar compounds, guangsangon E (), chalcomoracin (), and kuwanon J () were isolated from the EtOAc extract of liquid medium of var. root cultures. The structures of the isolated compounds were determined based on spectroscopic data, including 1D, 2D NMR, and MS data. Cytotoxic properties of compounds - were evaluated against murine leukemia P-388 cells. Morushalunin (), guangsangon E (), and chalcomoracin () were found to have significant cytotoxicity with IC values 0.7, 2.5, and 1.7 μg/mL, respectively, while kuwanon J () showed weak cytotoxicity (IC = 5.9 μg/mL).
从 var. 根培养物的液体培养基的 EtOAc 提取物中分离得到了一种新的 Diels-Alder 型加合物命名为 morushalunin ()，以及三种类似的化合物 guangsangon E ()、chalcomoracin () 和 kuwanon J ()。根据包括 1D、2D NMR 和 MS 数据在内的光谱数据确定了分离化合物的结构。对化合物 - 的细胞毒性进行了评估对 P-388 细胞的毒性。Morushalunin ()、guangsangon E () 和 chalcomoracin () 具有显著的细胞毒性，IC 值分别为 0.7、2.5 和 1.7μg/mL，而 kuwanon J () 表现出较弱的细胞毒性（IC = 5.9μg/mL）。
