糖缀合物：为疫苗开发掌握这些知名但知之甚少的免疫原需要什么。
Glycoconjugates: What It Would Take To Master These Well-Known yet Little-Understood Immunogens for Vaccine Development.
机构信息
Department of Biochemistry and Molecular Biology, Center for Molecular Medicine and Complex Carbohydrate Research Center, University of Georgia, Athens, Georgia, USA.
GSK Vaccines, Siena, Italy.
出版信息
mSphere. 2019 Sep 25;4(5):e00520-19. doi: 10.1128/mSphere.00520-19.
Abstract
Glycoconjugate vaccines are a critical component of the medical arsenal against infectious diseases. This established field continues, however, to experience failures in the clinic. The lack of fundamental understanding of factors controlling clinical efficacy of glycoconjugate vaccines is discussed while key parameters demanding focused and collaborative research are identified.
摘要
糖缀合物疫苗是对抗传染病的医学武器库中的重要组成部分。然而，这一成熟领域在临床应用中仍不断遭遇失败。本文讨论了缺乏对控制糖缀合物疫苗临床疗效的因素的基本认识，并确定了需要重点关注和协作研究的关键参数。
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