核苷类抗生素生物合成的最新进展。
Recent advances in the biosynthesis of nucleoside antibiotics.
机构信息
Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo, 113-8657, Japan.
Collaborative Research Institute for Innovative Microbiology (CRIIM), The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo, 113-8657, Japan.
出版信息
J Antibiot (Tokyo). 2019 Dec;72(12):913-923. doi: 10.1038/s41429-019-0236-2. Epub 2019 Sep 25.
Nucleoside antibiotics are a diverse class of natural products with promising biomedical activities. These compounds contain a saccharide core and a nucleobase. Despite the large number of nucleoside antibiotics that have been reported, biosynthetic studies on these compounds have been limited compared with those on other types of natural products such as polyketides, peptides, and terpenoids. Due to recent advances in genome sequencing technology, the biosynthesis of nucleoside antibiotics has rapidly been clarified. This review covering 2009-2019 focuses on recent advances in the biosynthesis of nucleoside antibiotics.
核苷类抗生素是一类具有广阔应用前景的生物活性天然产物，具有丰富的结构多样性。该类化合物通常包含糖基和碱基两个结构单元。尽管已报道的核苷类抗生素种类繁多，但与聚酮类、肽类和萜类等其他类型的天然产物相比，对其生物合成的研究相对较少。近年来，随着基因组测序技术的发展，核苷类抗生素的生物合成途径得到了快速阐明。本文对 2009 年至 2019 年期间的相关研究进行了综述，重点阐述了核苷类抗生素生物合成途径的最新研究进展。
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