Key Laboratory of Animal Nutrition and Feed Science (Eastern of China), Ministry of Agriculture, Key Laboratory of Animal Feed and Nutrition of Zhejiang Province, College of Animal Science, Zhejiang University, Hangzhou 310058, China.
Institute of Animal Husbandry and Veterinary Science, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China.
Biomed Pharmacother. 2019 Dec;120:109479. doi: 10.1016/j.biopha.2019.109479. Epub 2019 Sep 23.
Iron deficiency is the most common nutritional deficiency disorder in early postnatal period, which often manifesting into clinical complications. Therefore, iron supplementation is necessary to avoid iron deficiency anemia in the neonatal period. However, how to supplement iron effectively is a big problem. Thus, using newborn piglets as a model for iron deficiency, we compared the effects of routinely used protocol by intramuscular injection of high amount of iron dextran and a modified strategy by split iron supplementation with reduced amounts of iron. The results showed that split iron supplementation efficiently improved hematological status of piglets and attenuated the induction of hepcidin expression, which resulted in the recovery of piglets from iron deficiency and the increase of iron utilization. Compared with piglets received large amounts of iron dextran, low dose supplementation of iron improved the growth performance and duodenum development by increasing the villus height and crypt depth and enhancing microvilli morphology. Furthermore, split iron supplementation minimized the potential toxicity of the administered iron due to the oxidative stress and hepatocyte autophagy. Overall, the present study demonstrated that split supplementation with reduced amount of iron dextran not only protected newborn piglets from iron deficiency but also eliminated potential toxicity. It suggested that besides combating anemia, possible negative effects of excessive iron on oxidative stress, which is especially important for infant development, should be considered.
缺铁是新生儿期最常见的营养缺乏症，常导致临床并发症。因此，有必要补充铁剂以避免新生儿期缺铁性贫血。然而，如何有效地补充铁剂是一个大问题。因此，我们使用新生仔猪作为缺铁模型，比较了肌肉注射高剂量右旋糖酐铁的常规方案和减少铁剂用量的分剂量补充策略的效果。结果表明，分剂量补充铁剂能有效改善仔猪的血液学状态，减轻铁调素表达的诱导，从而使仔猪从缺铁中恢复，增加铁的利用。与接受大量右旋糖酐铁的仔猪相比，低剂量铁补充通过增加绒毛高度和隐窝深度以及增强微绒毛形态来提高仔猪的生长性能和十二指肠发育。此外，分剂量补充铁剂由于氧化应激和肝细胞自噬，最大限度地减少了给予铁剂的潜在毒性。总的来说，本研究表明，用减少剂量的右旋糖酐铁进行分剂量补充不仅可以保护新生仔猪免受缺铁的影响，还可以消除潜在的毒性。这表明，除了治疗贫血外，还应考虑过量铁对氧化应激的可能负面影响，这对婴儿发育尤其重要。
