Ho Andrew, Sinick Jonah, Esko Tõnu, Fischer Krista, Menni Cristina, Zierer Jonas, Matey-Hernandez Maria, Fortney Kristen, Morgen Eric K
BIOAGE, Richmond, CA 94804, USA.
Estonian Genome Center, University of Tartu, Tartu 51010, Estonia.
Aging (Albany NY). 2019 Sep 26;11(18):7694-7706. doi: 10.18632/aging.102281.
Glucuronic acid is a metabolite of glucose that is involved in the detoxification of xenobiotic compounds and the structure/remodeling of the extracellular matrix. We report for the first time that circulating glucuronic acid is a robust biomarker of mortality that is conserved across species. We find that glucuronic acid levels are significant predictors of all-cause mortality in three population-based cohorts from different countries with 4-20 years of follow-up (HR=1.44, p=2.9×10 in the discovery cohort; HR=1.13, p=0.032 and HR=1.25, p=0.017, respectively in the replication cohorts), as well as in a longitudinal study of genetically heterogenous mice (HR=1.29, p=0.018). Additionally, we find that glucuronic acid levels increase with age and predict future healthspan-related outcomes. Together, these results demonstrate glucuronic acid as a robust biomarker of longevity and healthspan.
葡萄糖醛酸是葡萄糖的一种代谢产物，参与外源性化合物的解毒以及细胞外基质的结构/重塑。我们首次报告，循环中的葡萄糖醛酸是一种在物种间保守的强有力的死亡生物标志物。我们发现，在来自不同国家、随访时间为4至20年的三个基于人群的队列中，葡萄糖醛酸水平是全因死亡率的显著预测指标（发现队列中HR = 1.44，p = 2.9×10；复制队列中HR分别为1.13，p = 0.032和HR = 1.25，p = 0.017），在一项对基因异质小鼠的纵向研究中也是如此（HR = 1.29，p = 0.018）。此外，我们发现葡萄糖醛酸水平随年龄增长而升高，并能预测未来与健康寿命相关的结果。总之，这些结果表明葡萄糖醛酸是一种强有力的长寿和健康寿命生物标志物。
