Division of Nutrition and Dietetics, College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Canada.
Division of Nutritional Sciences, Cornell University, Ithaca, NY, USA.
J Psychosom Obstet Gynaecol. 2020 Jun;41(2):144-153. doi: 10.1080/0167482X.2019.1666820. Epub 2019 Sep 27.
A favorable dietary composition to increase health-related quality of life (HRQoL) in PCOS remains unclear. We compared changes in HRQoL of women with PCOS who participated in a low-glycemic-index pulse-based (lentils, beans, split peas, and chickpeas) or the Therapeutic Lifestyle Changes (TLC) diet intervention. Thirty women in the pulse-based and 31 in the TLC groups (18-35 years) completed a 16-week intervention without energy-restriction. Groups participated in health counseling (monthly) and aerobic exercise (5 days/week; 45 minutes/day). Fifty-five (90.2%) women completed a PCOS-specific HRQoL survey. Greatest mean increases in time-effects occurred in the domains of healthy eating, PCOS knowledge, active living, healthcare satisfaction, feelings and experiences about intervention, and health concerns, respectively ( ≤ 0.02), without group-by-time interactions ( ≥ 0.13). Decreased weight ( = -0.35) and homeostatic model assessment of insulin resistance ( = -0.18) correlated with increased scores of PCOS knowledge; adherence to intervention correlated with increased scores of active living ( = 0.39) and healthy eating ( = 0.53; ≤ 0.03). Both interventions improved HRQoL scores in women with PCOS without prescribed energy-restriction. Our observations add novel insights into current evidence and elucidate the need for future psychological research to target lifestyle modifications for improving HRQoL and unique psychological complications of PCOS in this high-risk population (CinicalTrials.gov identifier:NCT01288638).
一种有利于提高多囊卵巢综合征患者健康相关生活质量（HRQoL）的饮食结构仍不清楚。我们比较了参加低血糖指数脉冲饮食（小扁豆、豆类、豌豆和鹰嘴豆）或治疗性生活方式改变（TLC）饮食干预的多囊卵巢综合征患者的 HRQoL 变化。基于脉冲的饮食组有 30 名女性，TLC 组有 31 名女性（18-35 岁），完成了 16 周的无能量限制干预。两组均接受健康咨询（每月一次）和有氧运动（每周 5 天；每天 45 分钟）。共有 55 名（90.2%）女性完成了多囊卵巢综合征特异性 HRQoL 调查。在健康饮食、多囊卵巢综合征知识、积极生活、医疗保健满意度、对干预的感受和体验以及健康担忧等方面，时间效应的平均增幅最大（≤0.02），且无组间时间交互作用（≥0.13）。体重下降（= -0.35）和稳态模型评估的胰岛素抵抗（= -0.18）与多囊卵巢综合征知识评分的增加相关；对干预的依从性与积极生活（=0.39）和健康饮食（=0.53；≤0.03）评分的增加相关。两种干预措施都改善了未经规定能量限制的多囊卵巢综合征患者的 HRQoL 评分。我们的观察结果为当前证据提供了新的见解，并阐明了未来需要进行心理研究，以针对生活方式的改变来改善这一高危人群的 HRQoL 和多囊卵巢综合征的独特心理并发症（临床试验标识符：NCT01288638）。
