School of Chemistry, Physics and Mechanical Engineering, Queensland University of Technology (QUT), 2 George Street, QLD, 4000, Brisbane, Australia.
Macromolecular Architectures, Institut für Technische Chemie und Polymerchemie, Karlsruhe Institute of Technology (KIT), Engesserstr. 18, 76131, Karlsruhe, Germany.
Chemistry. 2020 Jan 2;26(1):114-127. doi: 10.1002/chem.201904054. Epub 2019 Nov 19.
Chemiluminescence (CL) reactions have been widely employed and explored over the past 50 years because they offer unique light emission upon a defined chemical stimulus. In this Minireview, we focus on peroxyoxalate (PO) compounds because they feature very high quantum yields tuneable over the entire visible spectrum, allowing for visible-light detection by the naked eye without the necessity for expensive analytical instruments. Although analytical methods have been extensively described, PO-CL read-out is a strongly emerging field with ample industrial potential. The state-of-the-art PO-CL detection read-out systems for various key analytes is here explored. In particular, structural requirements, recent developments of PO-CL read-out probes and current limitations of selected examples are detailed. Furthermore, innovative approaches and synthetic routes to push the boundaries of PO-CL reactions into biological systems are highlighted. Underpinned by recent contributions, we share perspectives on embedding PO-CL molecules into polymeric materials, which they consider the next step in designing high performance solid-phase read-out systems.
化学发光 (CL) 反应在过去的 50 年中得到了广泛的应用和探索，因为它们在受到特定化学刺激时会产生独特的发光。在这篇综述中，我们专注于过氧草酸酯 (PO) 化合物，因为它们具有非常高的量子产率，可以在整个可见光谱范围内进行调节，使得可以用肉眼进行可见光检测，而无需昂贵的分析仪器。尽管已经广泛描述了分析方法，但 PO-CL 读出是一个具有巨大工业潜力的新兴领域。本文探讨了各种关键分析物的最先进的 PO-CL 检测读出系统。特别是，详细说明了 PO-CL 读出探针的结构要求、最新进展以及选定实例的当前局限性。此外，还强调了将 PO-CL 反应推向生物系统的创新方法和合成途径。基于最近的贡献，我们分享了将 PO-CL 分子嵌入聚合物材料中的观点，我们认为这是设计高性能固相读出系统的下一步。
