School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, PR China.
Analyst. 2020 Nov 23;145(23):7488-7510. doi: 10.1039/d0an01300e.
Chemiluminescence (CL) analysis is a trace analytical method that possesses advantages including high sensitivity, wide linear range, easy operation, and simple instruments. With the development of nanotechnology, many nanomaterial (NM)-enhanced CL systems have been established in recent years and applied for the CL detection of metal ions, anions, small molecules, tumor markers, sequence-specific DNA, and RNA. This review summarizes the research progress of the nanomaterial-enhanced CL systems the past five years. These CL reactions include luminol, peroxyoxalate, lucigenin, ultraweak CL reactions, and so on. The CL mechanisms of the nanomaterial-enhanced CL systems are discussed in the first section. Nanomaterials take part in the CL reactions as the catalyst, CL emitter, energy acceptor, and reductant. Their applications are summarized in the second section. Finally, the challenges and opportunities are discussed.
化学发光（CL）分析是一种痕量分析方法，具有灵敏度高、线性范围宽、操作简单、仪器简单等优点。随着纳米技术的发展，近年来建立了许多纳米材料（NM）增强的 CL 体系，并应用于金属离子、阴离子、小分子、肿瘤标志物、序列特异性 DNA 和 RNA 的 CL 检测。本文综述了近五年来纳米材料增强 CL 体系的研究进展。这些 CL 反应包括鲁米诺、过氧草酸盐、荧光素、超弱 CL 反应等。第一节讨论了纳米材料增强 CL 体系的 CL 机制。纳米材料作为催化剂、CL 发射器、能量受体和还原剂参与 CL 反应。在第二节中总结了它们的应用。最后讨论了挑战和机遇。
